CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009126
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger protein 121 
Protein Synonyms/Alias
 Zinc finger protein 20 
Gene Name
 ZNF121 
Gene Synonyms/Alias
 ZNF20 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
119GETLYEQKQCGRAFTubiquitination[1]
147VEKPYECKECGKFFRubiquitination[1]
179YECKECGKCFTVSSHubiquitination[1, 2]
203GEKPYQCKECGRAFAubiquitination[1]
235YECNECGKAYNRFYLubiquitination[3]
259EEKPFECKVCGKSFRubiquitination[1, 2]
263FECKVCGKSFRSSSCubiquitination[1]
272FRSSSCLKNHFRIHTubiquitination[1]
315GEKPYECKDCGKAFAubiquitination[1]
338IRTHTGEKPYICKECubiquitination[1]
343GEKPYICKECGKTFRubiquitination[1]
375YICNECGKAYNRFYLubiquitination[1]
385NRFYLLTKHLKTH**ubiquitination[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 88 110 C2H2-type 1; degenerate.
 ZN_FING 116 138 C2H2-type 2; degenerate.
 ZN_FING 144 166 C2H2-type 3.
 ZN_FING 172 194 C2H2-type 4.
 ZN_FING 200 222 C2H2-type 5.
 ZN_FING 228 250 C2H2-type 6.
 ZN_FING 256 278 C2H2-type 7.
 ZN_FING 284 306 C2H2-type 8.
 ZN_FING 312 334 C2H2-type 9.
 ZN_FING 340 362 C2H2-type 10.
 ZN_FING 368 390 C2H2-type 11.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MAEIHNGGEL CDFMENGEIF SEHSCLNAHM GTENTGDTYD CDEYGENFPM LHNSAPAGET 60
LSVLNQCRKA FSLPPNVHQR TWIGDKSFEY SDCEEAFVDQ SHLQANRITH NGETLYEQKQ 120
CGRAFTYSTS HAVSVKMHTV EKPYECKECG KFFRYSSYLN SHMRTHTGEK PYECKECGKC 180
FTVSSHLVEH VRIHTGEKPY QCKECGRAFA GRSGLTKHVR IHTGEKPYEC NECGKAYNRF 240
YLLTEHFKTH TEEKPFECKV CGKSFRSSSC LKNHFRIHTG IKPYKCKECG KAFTVSSSLH 300
NHVKIHTGEK PYECKDCGKA FATSSQLIEH IRTHTGEKPY ICKECGKTFR ASSHLQKHVR 360
IHTGEKPYIC NECGKAYNRF YLLTKHLKTH 390 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS