CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006591
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Spindle pole body component SPC42 
Protein Synonyms/Alias
  
Gene Name
 SPC42 
Gene Synonyms/Alias
 YKL042W; YKL255 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
13TPKRYSSKSSRLYDDacetylation[1]
176GNPRTTNKVSNTSDQubiquitination[2]
342CSNDLYEKNRVKPENubiquitination[2]
346LYEKNRVKPENNMSEubiquitination[2]
Reference
 [1] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane. 
Sequence Annotation
 MOD_RES 213 213 Phosphoserine.
 MOD_RES 217 217 Phosphoserine.
 MOD_RES 284 284 Phosphoserine.
 MOD_RES 329 329 Phosphoserine.  
Keyword
 3D-structure; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 363 AA 
Protein Sequence
MNGSPTPKRY SSKSSRLYDD YYNIPYQYSN PTPMNRDYND VGSRINADKL VPEEYKRNTE 60
FINKAVQQNK ELNFKLREKQ NEIFELKKIA ETLRSKLEKY VDITKKLEDQ NLNLQIKISD 120
LEKKLSDANS TFKEMRFPKV KDPMVDDDPV SENYDQINVP KHRAPDATGN PRTTNKVSNT 180
SDQDSRLKAI ERTLSVLTNY VMRSEDGNND RMSPLPSPLN TILPINNRLN FQEPKRYNPT 240
VKVNPSDDDI MMYESAELKR VEEEIEELKR KILVRKKHDL RKLSLNNQLQ ELQSMMDGDD 300
NIKLDNVSKH NHATHRHSSQ SSRDYSPSSD ACLECSNDLY EKNRVKPENN MSETFATPTP 360
NNR 363 
Gene Ontology
 GO:0005823; C:central plaque of spindle pole body; IDA:SGD.
 GO:0005821; C:intermediate layer of spindle pole body; IDA:SGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005200; F:structural constituent of cytoskeleton; IPI:SGD.
 GO:0007020; P:microtubule nucleation; IPI:SGD.
 GO:0007103; P:spindle pole body duplication associated with nuclear envelope; IMP:SGD. 
Interpro
 IPR021611; Spc42p. 
Pfam
 PF11544; Spc42p 
SMART
  
PROSITE
  
PRINTS