CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025321
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 Ldlr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
832FDNPVYQKTTEDELHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Disulfide bond; EGF-like domain; Membrane; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 862 AA 
Protein Sequence
MSTADLMRRW VIALLLAAAG VAAEDSCSRN EFQCRDGKCI ASKWVCDGSP ECPDGSDESP 60
ETCMSVTCQS NQFSCGGRVS RCIPDSWRCD GQVDCENDSD EQGCPPKTCS QDDFRCQDGK 120
CISPQFVCDG DRDCLDGSDE AHCQATTCGP AHFRCNSSIC IPSLWACDGD VDCVDGSDEW 180
PQNCQGRDTA SKGVSSPCSS LEFHCGSSEC IHRSWVCDGE ADCKDKSDEE HCAVATCRPD 240
EFQCADGSCI HGSRQCDREH DCKDMSDELG CVNVTQCDGP NKFKCHSGEC ISLDKVCDSA 300
RDCQDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGSECL CPSGFRLVDL HRCEDIDECQ 360
EPDTCSQLCV NLEGSYKCEC QAGFHMDPHT RVCKAVGSIG YLLFTNRHEV RKMTLDRSEY 420
TSLLPNLKNV VALDTEVTNN RIYWSDLSQK KIYSALMDQA PNLSYDTIIS EDLHAPDGLA 480
VDWIHRNIYW TDSVPGSVSV ADTKGVKRRT LFQEAGSRPR AIVVDPVHGF MYWTDWGTPA 540
KIKKGGLNGV DIHSLVTENI QWPNGITLDL SSGRLYWVDS KLHSISSIDV NGGNRKTILE 600
DENRLAHPFS LAIYEDKVYW TDVINEAIFS ANRLTGSDVN LVAENLLSPE DIVLFHKVTQ 660
PRGVNWCETT ALLPNGGCQY LCLPAPQIGP HSPKFTCACP DGMLLAKDMR SCLTEVDTVL 720
TTQGTSAVRP VVTASATRPP KHSEDLSAPS TPRQPVDTPG LSTVASVTVS HQVQGDMAGR 780
GNEEQPHGMR FLSIFFPIAL VALLVLGAVL LWRNWRLKNI NSINFDNPVY QKTTEDELHI 840
CRSQDGYTYP SRQMVSLEDG VA 862 
Gene Ontology
 GO:0005768; C:endosome; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0030169; F:low-density lipoprotein particle binding; IDA:MGI.
 GO:0005041; F:low-density lipoprotein receptor activity; IDA:MGI.
 GO:0030229; F:very-low-density lipoprotein particle receptor activity; IDA:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0008203; P:cholesterol metabolic process; IMP:MGI.
 GO:0030301; P:cholesterol transport; IMP:MGI.
 GO:0042159; P:lipoprotein catabolic process; IDA:MGI. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS