| Tag | Content |
|---|
| CPLM ID | CPLM-016364 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein phosphatase 1 regulatory subunit 15B |
Protein Synonyms/Alias | Constitutive repressor of eIF2alpha phosphorylation; CReP |
Gene Name | Ppp1r15b |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 116 | SAAPTVQKSLSSLRL | ubiquitination | [1] | | 563 | APFQPSGKNWKGRQD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. |
Sequence Annotation | MOD_RES 686 686 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 697 AA |
Protein Sequence | METGTHRARK RPGPRLGSWF RLPFLRRSHA CSSEFPPPSS RQNPGNSALP ERRTRYWTKL 60
LSQLLALLPS LFQKLLLWSQ LFGGLIPTRW LDFAASYSAL RALRGREESA APTVQKSLSS 120
LRLDSSEDLV VSSLDWLEEG LQWQCSSSDL ELKLKAQERA LDSAAPTFLL EQQLWGVELL 180
PSSLQAGLVS HRELDSSSSG PLSVQSLGNF KVVSYLLNPS YLDYLPQLGL RCQSSAGGGQ 240
FVGFRTLTPE SCYLSEDGCH PQPLRAEMSA TAWRRCPPLS TEGLPEIHHL RMKRLEFLQA 300
NKGQELPTPD QDNGYHSLEE EHNLLRMDPQ HCTDNPAQAV SPAADRPEPT EKKPELVIQE 360
VSQSPQGSSL FCELPVEKEC EEDHTNATDL SDRGESLPVS TRPVCSNKLI DYILGGAPSD 420
LEASSDSESE DWGEEPEDDG FDSDGSLSES DVEQDSEGLH LWNSFHSVDP YNPQNFTATI 480
QTAARIAPRD PSDSGTSWSG SCGVGSCQEG PLPETPDHSS GEEDDWEPSA DEAENLKLWN 540
SFCHSEDPYN LLNFKAPFQP SGKNWKGRQD SKASSEATVA FSGHHTLLSC KAQLLESQED 600
NCPGCGLGEA LAGERYTHIK RKKVTFLEEV TEYYISGDED RKGPWEEFAR DGCRFQKRIQ 660
ETEVAIGYCL AFEHREKMFN RLRIESKDLL LYSNVKK 697 |
Gene Ontology | GO:0000164; C:protein phosphatase type 1 complex; IDA:MGI. GO:0004722; F:protein serine/threonine phosphatase activity; IDA:MGI. GO:0045182; F:translation regulator activity; IC:MGI. GO:0006983; P:ER overload response; IMP:MGI. GO:0006446; P:regulation of translational initiation; IC:MGI. GO:0042542; P:response to hydrogen peroxide; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |