| Tag | Content |
|---|
| CPLM ID | CPLM-019875 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ufm1-specific protease 2 |
Protein Synonyms/Alias | UfSP2 |
Gene Name | Ufsp2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 181 | KCILRYMKGTSIVVP | ubiquitination | [1] | | 249 | HFPDELYKDGYIRNP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. |
Sequence Annotation | ACT_SITE 294 294
ACT_SITE 418 418
ACT_SITE 420 420 |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Endoplasmic reticulum; Hydrolase; Nucleus; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 461 AA |
Protein Sequence | MDILFRIRGG FDLAFQLAPP KEMFIKNALR QVLSDLTTKL SSDALVLRVC NSSVYLWPNS 60
DANTGELTDS SACKNVVRFI QFDQEEDTKR KFIKKKDKKL TDTQQIVNID LMLEISTPLG 120
AVTPILEREN EEHHYINMSL PIDAVVSVAP EESWGKVRKL LVDAILRQLV DVEKCILRYM 180
KGTSIVVPEP LHFQLPGKKN LVTVLYPSGI PDDQLQAYRK ELHDLFNLPH DRPYFKRINA 240
YHFPDELYKD GYIRNPHTYL SPPNIEGSMI CVVQGTYAYH HYMQDRIDDN GWGCAYRSLQ 300
TICSWFRHQG YTERSIPTHR EIQQALVDAG DKPATFVGSR QWIGSIEVQM VLNQLIGVTS 360
KILFVNQGSE MASQGRELAN HFQNVGTPVM VGGGVLAHTI LGVAWNETTG QIKFLILDPH 420
YTGAEDLQVM LEKGWCGWKS PDFWNKDAYY NLCLPQRPNA L 461 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0019783; F:small conjugating protein-specific protease activity; IDA:UniProtKB. GO:0016790; F:thiolester hydrolase activity; IDA:UniProtKB. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
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Pfam | |
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PROSITE | |
PRINTS | |