CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041976
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ElaC homolog 2 (E. coli), isoform CRA_a 
Protein Synonyms/Alias
 Zinc phosphodiesterase ELAC protein 2 
Gene Name
 ELAC2 
Gene Synonyms/Alias
 hCG_29734 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
80QRLMQEHKLKVARLDmethylation[1]
82LMQEHKLKVARLDNImethylation[1]
82LMQEHKLKVARLDNIubiquitination[2]
127SGPPQLEKYLEAIKIubiquitination[2, 3, 4]
133EKYLEAIKIFSGPLKubiquitination[2, 3, 5, 6]
313TFQRYQGKADAPVALubiquitination[2, 3]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 807 AA 
Protein Sequence
MWALCSLLRS AAGRTMSQGR TISQAPARRE RPRKDPLRHL RTREKRGPSG CSGGPNTVYL 60
QVVAAGSRDS GVQRLMQEHK LKVARLDNIF LTRMHWSNVG GLSGMILTLK ETGLPKCVLS 120
GPPQLEKYLE AIKIFSGPLK GIELAVRPHS APEYEDETMT VYQIPIHSEQ RRGKHQPWQS 180
PERPLSRLSP ERSSDSESNE NEPHLPHGVS QRRGVRDSSL VVAFICKLHL KRGNFLVLKA 240
KEMGLPVGTA AIAPIIAAVK DGKSITHEGR EILAEELCTP PDPGAAFVVV ECPDESFIQP 300
ICENATFQRY QGKADAPVAL VVHMAPASVL VDSRYQQWME RFGPDTQHLV LNENCASVHN 360
LRSHKIQTQL NLIHPDIFPL LTSFRCKKEG PTLSVPMVQG ECLLKYQLRP RREWQRDAII 420
TCNPEEFIVE ALQLPNFQQS VQEYRRSAQD GPAPAEKRSQ YPEIIFLGTG SAIPMKIRNV 480
SATLVNISPD TSLLLDCGEG TFGQLCRHYG DQVDRVLGTL AAVFVSHLHA DHHTGLPSIL 540
LQRERALASL GKPLHPLLVV APNQLKAWLQ QYHNQCQEVL HHISMIPAKC LQEGAEISSP 600
AVERLISSLL RTCDLEEFQT CLVRHCKHAF GCALVHTSGW KVVYSGDTMP CEALVRMGKD 660
ATLLIHEATL EDGLEEEAVE KTHSTTSQAI SVGMRMNAEF IMLNHFSQRY AKVPLFSPNF 720
SEKVGVAFDH MKVCFGDFPT MPKLIPPLKA LFAGDIEEME ERREKRELRQ VRAALLSREL 780
AGGLEDGEPQ QKRAHTEEPQ AKKVRAQ 807 
Gene Ontology
 GO:0016787; F:hydrolase activity; IEA:InterPro. 
Interpro
 IPR001279; Beta-lactamas-like. 
Pfam
  
SMART
 SM00849; Lactamase_B 
PROSITE
  
PRINTS