UniProt Accession

 AATC_YEAST; P23542; D6VY29 

Genbank Protein ID

 Z73199; BK006945 

Genbank Nucleotide ID

 CAA97550.1; DAA09345.1 

Protein Name

 Aspartate aminotransferase, cytoplasmic 

Protein Synonyms/Alias

 Transaminase A 

Gene Name

 AAT2 

Gene Synonyms/Alias

 ASP5; YLR027C; L1746 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
121	ISAKFFSKFFPDKLV	acetylation	[1]
255	FVCQSFAKNAGMYGE	ubiquitination	[2]
281	QAQNKTIKPAVTSQL	ubiquitination	[2]
290	AVTSQLAKIIRSEVS	acetylation	[1]
290	AVTSQLAKIIRSEVS	ubiquitination	[2]
305	NPPAYGAKIVAKLLE	ubiquitination	[2]
309	YGAKIVAKLLETPEL	acetylation	[1]
417	RFYTIEAKL******	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Plays a key role in amino acid metabolism. 

Sequence Annotation

 BINDING 38 38 Aspartate; via amide nitrogen.
 BINDING 135 135 Aspartate.
 BINDING 188 188 Aspartate.
 BINDING 387 387 Aspartate.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 255 255 N6-(pyridoxal phosphate)lysine.
 MOD_RES 389 389 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Aminotransferase; Complete proteome; Cytoplasm; Direct protein sequencing; Peroxisome; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005777; C:peroxisome; IMP:SGD.
 GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; ISS:UniProtKB.
 GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.
 GO:0006532; P:aspartate biosynthetic process; IMP:SGD.
 GO:0006536; P:glutamate metabolic process; ISS:UniProtKB. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR000796; Asp_trans.
 IPR004838; NHTrfase_class1_PyrdxlP-BS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

 PS00105; AA_TRANSFER_CLASS_1 

PRINTS

 PR00799; TRANSAMINASE.