UniProt Accession

 KAT3_RAT; Q58FK9 

Genbank Protein ID

 AY955395 

Genbank Nucleotide ID

 AAX55607.1 

Protein Name

 Kynurenine--oxoglutarate transaminase 3 

Protein Synonyms/Alias

 Cysteine-S-conjugate beta-lyase 2; Kynurenine aminotransferase III; KATIII; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III 

Gene Name

 Ccbl2 

Gene Synonyms/Alias

 Kat3 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
187	SKRTDGMKWTSSDWT	acetylation	[1]
203	NPQELESKFSSKTKA	acetylation	[1]
280	LTIGSAGKTFSVTGW	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By similarity). 

Sequence Annotation

 BINDING 53 53 Substrate (By similarity).
 BINDING 71 71 Substrate; via amide nitrogen (By
 BINDING 218 218 Substrate (By similarity).
 BINDING 429 429 Substrate (By similarity).
 MOD_RES 116 116 N6-acetyllysine (By similarity).
 MOD_RES 280 280 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Acetylation; Aminotransferase; Complete proteome; Lyase; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 454 AA 

Protein Sequence

Gene Ontology

 GO:0047804; F:cysteine-S-conjugate beta-lyase activity; IEA:EC.
 GO:0047315; F:kynurenine-glyoxylate transaminase activity; ISS:UniProtKB.
 GO:0016212; F:kynurenine-oxoglutarate transaminase activity; ISS:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0009058; P:biosynthetic process; IEA:InterPro. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

  

PRINTS