CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000942
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plexin-C1 
Protein Synonyms/Alias
 Virus-encoded semaphorin protein receptor; CD232 
Gene Name
 PLXNC1 
Gene Synonyms/Alias
 VESPR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
913LCKIKGIKTASTIANubiquitination[1]
924TIANSSKKVRVKLGNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). 
Sequence Annotation
 DOMAIN 35 452 Sema.
 MOD_RES 978 978 Phosphoserine (By similarity).
 CARBOHYD 86 86 N-linked (GlcNAc...).
 CARBOHYD 141 141 N-linked (GlcNAc...).
 CARBOHYD 149 149 N-linked (GlcNAc...).
 CARBOHYD 241 241 N-linked (GlcNAc...).
 CARBOHYD 252 252 N-linked (GlcNAc...).
 CARBOHYD 386 386 N-linked (GlcNAc...).
 CARBOHYD 407 407 N-linked (GlcNAc...).
 CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 582 582 N-linked (GlcNAc...) (Potential).
 CARBOHYD 653 653 N-linked (GlcNAc...) (Potential).
 CARBOHYD 692 692 N-linked (GlcNAc...) (Potential).
 CARBOHYD 771 771 N-linked (GlcNAc...) (Potential).
 CARBOHYD 796 796 N-linked (GlcNAc...) (Potential).
 CARBOHYD 821 821 N-linked (GlcNAc...) (Potential).
 CARBOHYD 890 890 N-linked (GlcNAc...) (Potential).
 DISULFID 64 87
 DISULFID 156 194
 DISULFID 226 354
 DISULFID 283 329
 DISULFID 455 472
 DISULFID 461 506
 DISULFID 464 481
 DISULFID 475 487  
Keyword
 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1568 AA 
Protein Sequence
MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA ASQEDGVFVA 60
SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR PGSSFSKLLL PYREGAAGLG 120
GLLLTGWTFD RGACEVRPLG NLSRNSLRNG TEVVSCHPQG STAGVVYRAG RNNRWYLAVA 180
ATYVLPEPET ASRCNPAASD HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW 240
NGSIYFPYYP YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV 300
EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA ESHCKEGDQP 360
ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL KVILGENLTS NCPEVIYEIK 420
EETPVFYKLV PDPVKNIYIY LTAGKEVRRI RVANCNKHKS CSECLTATDP HCGWCHSLQR 480
CTFQGDCVHS ENLENWLDIS SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD 540
SSRELCQNKS QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA 600
CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN KGNRTNQALQ 660
VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT STCDKDVIQV SHVLNDTHMK 720
FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY IALPHCSLIF PATTWISGGQ NITMMGRNFD 780
VIDNLIISHE LKGNINVSEY CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY 840
REDPRFTGYR VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ 900
DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV LPVLLVIVIF 960
AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ MDKLDVVDSF GTVPFLDYKH 1020
FALRTFFPES GGFTHIFTED MHNRDANDKN ESLTALDALI CNKSFLVTVI HTLEKQKNFS 1080
VKDRCLFASF LTIALQTKLV YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW 1140
MSVCLSGFLR ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA 1200
LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG LQLNEIGLEL 1260
QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI KVFKKIANFT SDVEYSDDHC 1320
HLILPDSEAF QDVQGKRHRG KHKFKVKEMY LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA 1380
PFAIKYFFDF LDAQAENKKI TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG 1440
CLSVIAQAFM DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM 1500
EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK QLLHVKVLFD 1560
EKKKCKWM 1568 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR013548; Plexin_cytoplasmic_RasGAP_dom.
 IPR002165; Plexin_repeat.
 IPR008936; Rho_GTPase_activation_prot.
 IPR001627; Semaphorin/CD100_Ag.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF08337; Plexin_cytopl
 PF01437; PSI
 PF01833; TIG 
SMART
 SM00429; IPT
 SM00423; PSI 
PROSITE
 PS51004; SEMA 
PRINTS