CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017333
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase PDIK1L 
Protein Synonyms/Alias
 PDLIM1-interacting kinase 1-like 
Gene Name
 PDIK1L 
Gene Synonyms/Alias
 CLIK1L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MVSSQPKYDLIREVubiquitination[1]
166QIIHRDLKPDNILISubiquitination[1, 2]
187SDLEPTLKVADFGLSubiquitination[1, 3]
195VADFGLSKVCSASGQubiquitination[1]
271ELLGSYVKQGTEIVPubiquitination[3]
288EALLENPKMELLIPVubiquitination[1]
335RLVQIAFKDSSWET*ubiquitination[1, 2, 3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 
Functional Description
  
Sequence Annotation
 DOMAIN 8 334 Protein kinase.
 NP_BIND 14 22 ATP (By similarity).
 ACT_SITE 164 164 Proton acceptor (By similarity).
 BINDING 37 37 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA LREFWALSSI 60
KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS LKGEIAFDPR SAYYLWFVMD 120
FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS ALAFLHKNQI IHRDLKPDNI LISQTRLDTS 180
DLEPTLKVAD FGLSKVCSAS GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI 240
FALGIIIWAM LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM 300
NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T 341 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS