| Tag | Content |
|---|
| CPLM ID | CPLM-006113 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 |
Protein Synonyms/Alias | Phosphoinositide phospholipase C; Phospholipase C-1; PLC-1 |
Gene Name | PLC1 |
Gene Synonyms/Alias | YPL268W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 554 | NEQELRMKDDSTNSS | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1. |
Sequence Annotation | DOMAIN 269 304 EF-hand.
DOMAIN 382 520 PI-PLC X-box.
DOMAIN 590 709 PI-PLC Y-box.
DOMAIN 734 846 C2.
ACT_SITE 395 395 By similarity.
ACT_SITE 439 439 By similarity.
BINDING 518 518 Substrate (By similarity).
BINDING 520 520 Substrate (By similarity).
BINDING 614 614 Substrate (By similarity).
BINDING 643 643 Substrate (By similarity). |
Keyword | Calcium; Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Metal-binding; Reference proteome; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 869 AA |
Protein Sequence | MTESAIDDQR FNLTKELQRH SCRDQGKITQ KDDALDFISY SSFQSSFNTD QKSANNGSTV 60
RRSIRSIFRR AAELPRVHMG PLTYSHGINE LVNKKLRKDC DLSTLCRVLQ RGIRMIRMTR 120
RRRKFYEFKL INNNGQIIWK DGSKYLELDS VKDIRIGDTA STYQEEVDPK RLRSDSKLWI 180
AIIYKVSNKL KALHVVALNE LDFNTFLSCI CGLVKLRREL MESILLPDNS QFARIHWQIT 240
VSEKEEDEKK DTLSFADVKK LCDKFHIYVS TGQLLEFFQL ADINHNGLLN YFEFEKFIKI 300
LKNRKEVNMI WSKFTKPPHS HLSFENFFQF LITEQHEQVD RQTAWSYFIK YREPTQLTMG 360
QDGFTKFLKE QPYLVEVKEE LYSKPLNHYF IASSHNTYLL GKQIAETPSV EGYIQVLQQG 420
CRCVEIDIWD GENGPVVCHG FLTSAIPLKT VIRVIKKYAF ITSPYPLIIS LEINCNKDNQ 480
KLASLIMREV LAEQLYFVGT RTDKLPSPRE LKHKILLKSK KTSEATRGLS VNEPFPSSFS 540
SSYESANEQE LRMKDDSTNS SSATNSSSMQ RIKRIGLKKH ADIINDVSNI SGIHGIKFRN 600
FSLPESKTIA HCFSLNERKV EYMIKDKHLK LSLDKHNRRY LMRVYPHVLR YKSSNFNPIP 660
FWKAGVQMVA TNWQTNDIGQ QLNLAMFQIL DHQPDGSFKS GYVLKPKKLL PVVTKAKMIP 720
LIYEHFENGS DPVTVKIRIL STQLLPRLND TSPSRNNTNS FVKVEFHTDD EPTMPISIDK 780
GTRISATEAS TKSSQGNGFN PIWDAEVSIT LKDTDLTFIK FMVISEETQI ASVCLKLNYL 840
RMGYRHIPLF NMEGEQYIFC TLFIHTQIL 869 |
Gene Ontology | GO:0000778; C:condensed nuclear chromosome kinetochore; IPI:SGD. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:SGD. GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. GO:0032958; P:inositol phosphate biosynthetic process; IMP:SGD. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0009395; P:phospholipid catabolic process; IDA:SGD. GO:0034501; P:protein localization to kinetochore; IMP:SGD. GO:0001402; P:signal transduction involved in filamentous growth; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |