| Tag | Content |
|---|
| CPLM ID | CPLM-008120 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Deoxyribonuclease-1 |
Protein Synonyms/Alias | Deoxyribonuclease I; DNase I |
Gene Name | Dnase1 |
Gene Synonyms/Alias | Dnl1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 72 | SHLVAVGKLLDELNR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). |
Sequence Annotation | ACT_SITE 100 100 By similarity.
ACT_SITE 156 156 By similarity.
CARBOHYD 40 40 N-linked (GlcNAc...) (Potential).
CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
DISULFID 123 126 By similarity.
DISULFID 195 231 Essential for enzymatic activity (By |
Keyword | Actin-binding; Apoptosis; Calcium; Complete proteome; Disulfide bond; Endonuclease; Glycoprotein; Hydrolase; Nuclease; Nucleus; Reference proteome; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 284 AA |
Protein Sequence | MRYTGLMGTL LTLVNLLQLA GTLRIAAFNI RTFGETKMSN ATLSVYFVKI LSRYDIAVIQ 60
EVRDSHLVAV GKLLDELNRD KPDTYRYVVS EPLGRKSYKE QYLFVYRPDQ VSILDSYQYD 120
DGCEPCGNDT FSREPAIVKF FSPYTEVQEF AIVPLHAAPT EAVSEIDALY DVYLDVWQKW 180
GLEDIMFMGD FNAGCSYVTS SQWSSIRLRT SPIFQWLIPD SADTTVTSTH CAYDRIVVAG 240
ALLQAAVVPN SAVPFDFQAE YGLSNQLAEA ISDHYPVEVT LRKI 284 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. GO:0004530; F:deoxyribonuclease I activity; IEA:EC. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0006308; P:DNA catabolic process; IEA:InterPro. GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |