| Tag | Content |
|---|
| CPLM ID | CPLM-019187 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myotubularin-related protein 8 |
Protein Synonyms/Alias | |
Gene Name | MTMR8 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 128 | EMRESGWKLIDPISD | ubiquitination | [1] | | 255 | MANRAAGKGYENEDN | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable). |
Sequence Annotation | DOMAIN 126 500 Myotubularin phosphatase.
REGION 250 253 Substrate binding (By similarity).
REGION 275 276 Substrate binding (By similarity).
REGION 338 344 Substrate binding (By similarity).
MOTIF 338 344 Active site.
ACT_SITE 338 338 Phosphocysteine intermediate (By
BINDING 384 384 Substrate (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Hydrolase; Nucleus; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 704 AA |
Protein Sequence | MDHITVPKVE NVKLVDRYVS KKPANGILYL TATHLIYVEA SGAARKETWI ALHHIATVEK 60
LPITSLGCPL TLRCKNFRVA HFVLDSDLVC HEVYISLLKL SQPALPEDLY AFSYNPKSSK 120
EMRESGWKLI DPISDFGRMG IPNRNWTITD ANRNYEICST YPPEIVVPKS VTLGTVVGSS 180
KFRSKERVPV LSYLYKENNA AICRCSQPLS GFYTRCVDDE LLLEAISQTN PGSQFMYVVD 240
TRPKLNAMAN RAAGKGYENE DNYANIRFRF MGIENIHVMR SSLQKLLEVC ELKTPTMSEF 300
LSGLESSGWL RHIKAIMDAG IFITKAVKVE KASVLVHCSD GWDRTAQVCS VASILLDPFY 360
RTFKGLMILI EKEWISMGHK FSQRCGHLDG DSKEVSPIFT QFLDCIWQLM EQFPCAFEFN 420
ENFLLEIHDH VFSCQFGNFL GNCQKDREDL RVYEKTHSVW PFLVQRKPDF RNPLYKGFTM 480
YGVLNPSTVP YNIQFWCGMY NRFDKGLQPK QSMLESLLEI KKQRAMLETD VHELEKKLKV 540
RDEPPEEICT CSQLGNILSQ HLGSPLTNPL GFMGINGDLN TLMENGTLSR EGGLRAQMDQ 600
VKSQGADLHH NCCEIVGSLR AINISGDVGI SEAMGISGDM CTFEATGFSK DLGICGAMDI 660
SEATGISGNL GISEARGFSG DMGILGDTGI SKASTKEADY SKHQ 704 |
Gene Ontology | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |