CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010002
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucosyl-3-phosphoglycerate phosphatase 
Protein Synonyms/Alias
 GpgP; Mannosyl-3-phosphoglycerate phosphatase; MpgP 
Gene Name
 gpgP 
Gene Synonyms/Alias
 Rv2419c; MT2492 
Created Date
 July 27, 2013 
Organism
 Mycobacterium tuberculosis 
NCBI Taxa ID
 1773 
Lysine Modification
Position
Peptide
Type
References
47AAAEVLGKRQPLLIVpupylation[1]
Reference
 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036
Functional Description
 Involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) to glucosylglycerate (GG). GPG is the preferred substrate,but a lower activity is measured with mannosyl-3-phosphoglycerate (MPG) and mannosylglucosyl-3-phosphoglycerate (MGPG). 
Sequence Annotation
 ACT_SITE 11 11 Tele-phosphohistidine intermediate (By
 ACT_SITE 159 159 By similarity.
 CROSSLNK 47 47 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 Complete proteome; Hydrolase; Isopeptide bond; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 223 AA 
Protein Sequence
MRARRLVMLR HGQTDYNVGS RMQGQLDTEL SELGRTQAVA AAEVLGKRQP LLIVSSDLRR 60
AYDTAVKLGE RTGLVVRVDT RLRETHLGDW QGLTHAQIDA DAPGARLAWR EDATWAPHGG 120
ESRVDVAARS RPLVAELVAS EPEWGGADEP DRPVVLVAHG GLIAALSAAL LKLPVANWPA 180
LGGMGNASWT QLSGHWAPGS DFESIRWRLD VWNASAQVSS DVL 223 
Gene Ontology
 GO:0050531; F:mannosyl-3-phosphoglycerate phosphatase activity; IEA:EC. 
Interpro
 IPR013078; His_Pase_superF_clade-1.
 IPR001345; PG/BPGM_mutase_AS. 
Pfam
 PF00300; His_Phos_1 
SMART
 SM00855; PGAM 
PROSITE
 PS00175; PG_MUTASE 
PRINTS