UniProt Accession

 QOR_MOUSE; P47199; Q62508; Q99L63 

Genbank Protein ID

 S70056; BC003800; D78646 

Genbank Nucleotide ID

 AAB30620.2; AAH03800.1; BAA11463.1 

Protein Name

 Quinone oxidoreductase 

Protein Synonyms/Alias

 NADPH:quinone reductase; Zeta-crystallin 

Gene Name

 Cryz 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	RSGAYSRKPALPYTP	ubiquitination	[1]
186	TAGSEEGKKLVLQNG	acetylation	[2, 3]
186	TAGSEEGKKLVLQNG	succinylation	[3]
187	AGSEEGKKLVLQNGA	ubiquitination	[1]
208	KEANYIDKIKMSVGD	acetylation	[3, 4]
208	KEANYIDKIKMSVGD	succinylation	[3]
208	KEANYIDKIKMSVGD	ubiquitination	[1]
216	IKMSVGDKDKGVDVI	acetylation	[4]
298	GIEKGWVKPVIGSEY	acetylation	[3, 4]
298	GIEKGWVKPVIGSEY	succinylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). 

Sequence Annotation

 NP_BIND 158 161 NADP (By similarity).
 NP_BIND 248 251 NADP (By similarity).
 NP_BIND 271 273 NADP (By similarity).
 BINDING 53 53 NADP (By similarity).
 BINDING 181 181 NADP; via amide nitrogen (By similarity).
 BINDING 200 200 NADP (By similarity).
 BINDING 231 231 NADP (By similarity).
 MOD_RES 23 23 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0003730; F:mRNA 3'-UTR binding; ISS:UniProtKB.
 GO:0070402; F:NADPH binding; ISS:UniProtKB.
 GO:0003960; F:NADPH:quinone reductase activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0042178; P:xenobiotic catabolic process; ISS:UniProtKB. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom.
 IPR002364; Quin_OxRdtase/zeta-crystal_CS. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS01162; QOR_ZETA_CRYSTAL 

PRINTS