CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013403
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA polymerase III subunit beta 
Protein Synonyms/Alias
  
Gene Name
 dnaN 
Gene Synonyms/Alias
 MPN_001; MP153 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
101KDQTLLVKTKKTNINacetylation[1]
129FNQNVDLKEFDELKIacetylation[1]
135LKEFDELKIQHSLLTacetylation[1]
229IFFRKEHKDDLSTELacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 380 AA 
Protein Sequence
MKVLINKNEL NKILKKLNNV IVSNNKMKPY HSYLLIEATE KEINFYANNE YFSAKCTLAE 60
NIDVLEEGEV IVKGKIFSEL INGIKEDIIT IQEKDQTLLV KTKKTNINLN TIDKKEFPRI 120
RFNQNVDLKE FDELKIQHSL LTKGLKKIAH AVSTFRESTR KFNGVNFNGS NGKQIFLEAS 180
DSYKLSVYEI KQKTDPFNFI VETNLLSFIN SFNPEGGDLI SIFFRKEHKD DLSTELLIKL 240
DNFLINYTSI NESFPRVMQL FDFEPETKVT IQKNELKDAL QRILTLAQNE RFFLCDMQVT 300
NSHLKINSNV QNIGASLEEV TCLKFEGHKL NIAVNALSLL EHIDSFDTDE IELYFQGSNK 360
YFLISSNNEP ELKEILVPSK 380 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
 GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 
Interpro
 IPR001001; DNA_polIII_beta.
 IPR022635; DNA_polIII_beta_C.
 IPR022637; DNA_polIII_beta_cen.
 IPR022634; DNA_polIII_beta_N. 
Pfam
 PF00712; DNA_pol3_beta
 PF02767; DNA_pol3_beta_2
 PF02768; DNA_pol3_beta_3 
SMART
 SM00480; POL3Bc 
PROSITE
  
PRINTS