CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015941
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MAM domain-containing glycosylphosphatidylinositol anchor protein 2 
Protein Synonyms/Alias
 MAM domain-containing protein 1 
Gene Name
 MDGA2 
Gene Synonyms/Alias
 MAMDC1; UNQ8188/PRO23197 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
722VRLTPLTKFGEGDSTubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 May involved in cell-cell interactions (By similarity). 
Sequence Annotation
 DOMAIN 27 127 Ig-like 1.
 DOMAIN 134 232 Ig-like 2.
 DOMAIN 242 328 Ig-like 3.
 DOMAIN 340 436 Ig-like 4.
 DOMAIN 442 533 Ig-like 5.
 DOMAIN 540 627 Ig-like 6.
 DOMAIN 746 921 MAM.
 LIPID 931 931 GPI-anchor amidated aspartate
 CARBOHYD 92 92 N-linked (GlcNAc...) (Potential).
 CARBOHYD 213 213 N-linked (GlcNAc...) (Potential).
 CARBOHYD 237 237 N-linked (GlcNAc...) (Potential).
 CARBOHYD 434 434 N-linked (GlcNAc...) (Potential).
 CARBOHYD 443 443 N-linked (GlcNAc...) (Potential).
 CARBOHYD 504 504 N-linked (GlcNAc...) (Potential).
 CARBOHYD 610 610 N-linked (GlcNAc...) (Potential).
 CARBOHYD 703 703 N-linked (GlcNAc...) (Potential).
 DISULFID 62 110 By similarity.
 DISULFID 159 216 By similarity.
 DISULFID 264 310 By similarity.
 DISULFID 359 417 By similarity.
 DISULFID 465 515 By similarity.
 DISULFID 561 611 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 956 AA 
Protein Sequence
MDLLYGLVWL LTVLLEGISG QGVYAPPTVR IVHSGLACNI EEERYSERVY TIREGETLEL 60
TCLVTGHPRP QIRWTKTAGS ASDRFQDSSV FNETLRITNI QRHQGGRYYC KAENGLGSPA 120
IKSIRVDVYY LDDPVVTVHQ SIGEAKEQFY YERTVFLRCV ANSNPPVRYS WRRGQEVLLQ 180
GSDKGVEIYE PFFTQGETKI LKLKNLRPQD YANYSCIASV RNVCNIPDKM VSFRLSNKTA 240
SPSIKLLVDD PIVVNPGEAI TLVCVTTGGE PAPSLTWVRS FGTLPEKTVL NGGTLTIPAI 300
TSDDAGTYSC IANNNVGNPA KKSTNIIVRA LKKGRFWITP DPYHKDDNIQ IGREVKISCQ 360
VEAVPSEELT FSWFKNGRPL RSSERMVITQ TDPDVSPGTT NLDIIDLKFT DFGTYTCVAS 420
LKGGGISDIS IDVNISSSTV PPNLTVPQEK SPLVTREGDT IELQCQVTGK PKPIILWSRA 480
DKEVAMPDGS MQMESYDGTL RIVNVSREMS GMYRCQTSQY NGFNVKPREA LVQLIVQYPP 540
AVEPAFLEIR QGQDRSVTMS CRVLRAYPIR VLTYEWRLGN KLLRTGQFDS QEYTEYAVKS 600
LSNENYGVYN CSIINEAGAG RCSFLVTGKA YAPEFYYDTY NPVWQNRHRV YSYSLQWTQM 660
NPDAVDRIVA YRLGIRQAGQ QRWWEQEIKI NGNIQKGELI TYNLTELIKP EAYEVRLTPL 720
TKFGEGDSTI RVIKYSAPVN PHLREFHCGF EDGNICLFTQ DDTDNFDWTK QSTATRNTKY 780
TPNTGPNADR SGSKEGFYMY IETSRPRLEG EKARLLSPVF SIAPKNPYGP TNTAYCFSFF 840
YHMYGQHIGV LNVYLRLKGQ TTIENPLWSS SGNKGQRWNE AHVNIYPITS FQLIFEGIRG 900
PGIEGDIAID DVSIAEGECA KQDLATKNSV DGAVGILVHI WLFPIIVLIS ILSPRR 956 
Gene Ontology
 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0021522; P:spinal cord motor neuron differentiation; ISS:HGNC. 
Interpro
 IPR008985; ConA-like_lec_gl_sf.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR000998; MAM_dom. 
Pfam
 PF07679; I-set
 PF00629; MAM 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00137; MAM 
PROSITE
 PS50835; IG_LIKE
 PS00740; MAM_1
 PS50060; MAM_2 
PRINTS