CPLM-036571

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-036571

UniProt Accession

Genbank Protein ID

HQ206226; HQ206227; HQ206228; HQ206229; HQ206230; HQ206231; HQ206232; HQ206233; HQ206234; HQ206235; HQ206236; HQ206237; HQ206238; HQ206239; HQ206240; HQ206241; HQ206242; HQ206243; HQ206244; HQ206245; HQ206246; HQ206247; HQ206248; HQ206249; HQ206250; HQ206251; HQ206252; HQ206253; HQ206254; HQ206255; HQ206256; HQ206257; HQ206258; HQ206259; HQ206260; HQ206261; HQ206262; HQ206263; HQ206264; HQ206265

Genbank Nucleotide ID

ADP92134.1; ADP92136.1; ADP92138.1; ADP92140.1; ADP92142.1; ADP92144.1; ADP92146.1; ADP92148.1; ADP92150.1; ADP92152.1; ADP92154.1; ADP92156.1; ADP92158.1; ADP92160.1; ADP92162.1; ADP92164.1; ADP92166.1; ADP92168.1; ADP92170.1; ADP92172.1; ADP92174.1; ADP92176.1; ADP92178.1; ADP92180.1; ADP92182.1; ADP92184.1; ADP92186.1; ADP92188.1; ADP92190.1; ADP92192.1; ADP92194.1; ADP92196.1; ADP92198.1; ADP92200.1; ADP92202.1; ADP92204.1; ADP92206.1; ADP92208.1; ADP92210.1; ADP92212.1

Protein Name

Uracil-DNA glycosylase

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
5	***MIGQKTLYSFFS	ubiquitination	[1]

Reference

[1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).

Sequence Annotation

Keyword

DNA damage; DNA repair; Glycosidase; Hydrolase.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

313 AA

Protein Sequence

MIGQKTLYSF FSPSPARKRH APSPEPAVQG TGVAGVPEES GDAAAIPAKK APAGQEEPGT 60
PPSSPLSAEQ LDRIQRNKAA ALLRLAARNV PVGFGESWKK HLSGEFGKPY FIKLMGFVAE 120
ERKHYTVYPP PHQVFTWTQM CDIKDVKVVI LGQDPYHGPN QAHGLCFSVQ RPVPPPPSLE 180
NIYKELSTDI EDFVHPGHGD LSGWAKQGVL LLNAVLTVRA HQANSHKERG WEQFTDAVVS 240
WLNQNSNGLV FLLWGSYAQK KGSAIDRKRH HVLQTAHPSP LSVYRGFFGC RHFSKTNELL 300
QKSGKKPIDW KEL 313

Gene Ontology

GO:0005739; C:mitochondrion; IEA:Compara.
GO:0005634; C:nucleus; IEA:Compara.
GO:0004844; F:uracil DNA N-glycosylase activity; IEA:Compara.
GO:0006284; P:base-excision repair; IEA:InterPro.
GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Compara.
GO:0016447; P:somatic recombination of immunoglobulin gene segments; IEA:Compara.

Interpro

IPR018085; Ura-DNA_Glyclase_AS.
IPR002043; Ura_DNA_glycsylse.
IPR005122; Uracil-DNA_glycosylase-like.

Pfam

PF03167; UDG

SMART

SM00986; UDG

PROSITE

PS00130; U_DNA_GLYCOSYLASE

PRINTS