UniProt Accession

 ANXA5_MOUSE; P48036; Q3U5Q1; Q3U5X4; Q3U8K1; Q3UGV0; Q99LA1 

Genbank Protein ID

 U29396; D63423; AJ230108; AJ230110; AJ230111; AJ230114; AJ230116; AJ230118; AJ230119; AJ230120; AJ230121; AJ230122; AJ230123; AJ230124; AK147740; AK152185; AK153388; AK153476; BC003716 

Genbank Nucleotide ID

 AAC52530.1; BAA09728.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; CAA13092.1; BAE28107.1; BAE31016.1; BAE31952.1; BAE32026.1; AAH03716.1 

Protein Name

 Annexin A5 

Protein Synonyms/Alias

 Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha 

Gene Name

 Anxa5 

Gene Synonyms/Alias

 Anx5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	EVLRKAMKGLGTDED	ubiquitination	[1]
56	QEIAQEFKTLFGRDL	acetylation	[2]
56	QEIAQEFKTLFGRDL	ubiquitination	[1]
68	RDLVDDLKSELTGKF	acetylation	[2, 3, 4, 5, 6]
68	RDLVDDLKSELTGKF	ubiquitination	[1]
74	LKSELTGKFEKLIVA	acetylation	[2, 5]
74	LKSELTGKFEKLIVA	ubiquitination	[1]
77	ELTGKFEKLIVAMMK	acetylation	[2, 4]
84	KLIVAMMKPSRLYDA	acetylation	[5]
84	KLIVAMMKPSRLYDA	ubiquitination	[1]
95	LYDAYELKHALKGAG	acetylation	[2, 5, 6]
95	LYDAYELKHALKGAG	ubiquitination	[1]
99	YELKHALKGAGTDEK	acetylation	[2]
99	YELKHALKGAGTDEK	ubiquitination	[1]
106	KGAGTDEKVLTEIIA	acetylation	[2]
106	KGAGTDEKVLTEIIA	ubiquitination	[1]
191	KWGTDEEKFITIFGT	acetylation	[2]
240	QLLLAVVKSIRSIPA	acetylation	[2]
288	NIRKEFRKNFATSLY	acetylation	[2, 6]
288	NIRKEFRKNFATSLY	succinylation	[6]
288	NIRKEFRKNFATSLY	ubiquitination	[1]
299	TSLYSMIKGDTSGDY	acetylation	[2, 5]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. 

Sequence Annotation

 REPEAT 22 82 Annexin 1.
 REPEAT 94 154 Annexin 2.
 REPEAT 178 238 Annexin 3.
 REPEAT 253 313 Annexin 4.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 74 74 N6-acetyllysine (By similarity).
 MOD_RES 77 77 N6-acetyllysine (By similarity).
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 99 99 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Annexin; Blood coagulation; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Hemostasis; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0072563; C:endothelial microparticle; IDA:BHF-UCL.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0005622; C:intracellular; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
 GO:0050819; P:negative regulation of coagulation; IEA:InterPro.
 GO:0010033; P:response to organic substance; IDA:MGI. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR015473; Annexins_V.
 IPR002392; AnnexinV. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00201; ANNEXINV.