CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021738
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vesicular glutamate transporter 2 
Protein Synonyms/Alias
 VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 
Gene Name
 Slc17a6 
Gene Synonyms/Alias
 Dnpi; Vglut2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
561WPNGWEKKEEFVQESubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate. 
Sequence Annotation
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 CARBOHYD 470 470 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell junction; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Ion transport; Membrane; Neurotransmitter transport; Reference proteome; Sodium; Sodium transport; Symport; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 582 AA 
Protein Sequence
MESVKQRILA PGKEGIKNFA GKSLGQIYRV LEKKQDNRET IELTEDGKPL EVPEKKAPLC 60
DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD 120
PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV 180
IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT 240
GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 300
TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT 360
IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV 420
GFSGFAISGF NVNHLDIAPR YASILMGISN GVGTLSGMVC PIIVGAMTKN KSREEWQYVF 480
LIAALVHYGG VIFYALFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT 540
TKSYGATSQE NGGWPNGWEK KEEFVQESAQ DAYSYKDRDD YS 582 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005769; C:early endosome; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; TAS:RGD.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005313; F:L-glutamate transmembrane transporter activity; IDA:RGD.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0001504; P:neurotransmitter uptake; TAS:RGD.
 GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. 
Interpro
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS