UniProt Accession

 BMX_HUMAN; P51813; A6NIH9; O60564; Q12871 

Genbank Protein ID

 X83107; AF045459; AC097625; CH471074; BC016652; U08341 

Genbank Nucleotide ID

 CAA58169.1; AAC08966.1; EAW98889.1; AAH16652.1; AAA17744.1 

Protein Name

 Cytoplasmic tyrosine-protein kinase BMX 

Protein Synonyms/Alias

 Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38 

Gene Name

 BMX 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
413	GNGIWELKREEITLL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. 

Sequence Annotation

 DOMAIN 4 111 PH.
 DOMAIN 296 392 SH2.
 DOMAIN 417 675 Protein kinase.
 ZN_FING 113 149 Btk-type.
 NP_BIND 423 431 ATP (By similarity).
 MOTIF 596 603 CAV1-binding.
 ACT_SITE 536 536 Proton acceptor (By similarity).
 METAL 121 121 Zinc (By similarity).
 METAL 132 132 Zinc (By similarity).
 METAL 133 133 Zinc (By similarity).
 METAL 143 143 Zinc (By similarity).
 BINDING 445 445 ATP (By similarity).
 MOD_RES 216 216 Phosphotyrosine; by autocatalysis.
 MOD_RES 224 224 Phosphotyrosine; by autocatalysis.
 MOD_RES 566 566 Phosphotyrosine; by SRC and  

Keyword

 3D-structure; Apoptosis; ATP-binding; Cell adhesion; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; Stress response; Transferase; Tyrosine-protein kinase; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 675 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0032587; C:ruffle membrane; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; TAS:ProtInc.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007498; P:mesoderm development; TAS:ProtInc.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR000980; SH2.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR001562; Znf_Btk_motif. 

Pfam

 PF00779; BTK
 PF00169; PH
 PF07714; Pkinase_Tyr
 PF00017; SH2 

SMART

 SM00107; BTK
 SM00233; PH
 SM00252; SH2
 SM00219; TyrKc 

PROSITE

 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS50001; SH2
 PS51113; ZF_BTK 

PRINTS

 PR00401; SH2DOMAIN.
 PR00402; TECBTKDOMAIN.
 PR00109; TYRKINASE.