CPLM-022991

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-022991

UniProt Accession

LCMT1_HUMAN; Q9UIC8; A6NL89; A8K770; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9Y378

Genbank Protein ID

AF037601; AF151826; AK025884; AK223364; AK291885; AK314409; AC008741; AC133552; BC001214; BC014217; AL137283

Genbank Nucleotide ID

AAF18267.1; AAD34063.1; BAB15270.1; BAD97084.1; BAF84574.1; BAG37031.1; AAH01214.1; AAH14217.1; CAB70677.1

Protein Name

Leucine carboxyl methyltransferase 1

Protein Synonyms/Alias

Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

Gene Name

LCMT1

Gene Synonyms/Alias

LCMT; CGI-68

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
105	HGVSQLIKAFLRKTE	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

Sequence Annotation

REGION 171 172 S-adenosyl-L-methionine binding.
BINDING 73 73 S-adenosyl-L-methionine.
BINDING 98 98 S-adenosyl-L-methionine; via carbonyl
BINDING 122 122 S-adenosyl-L-methionine.
BINDING 198 198 S-adenosyl-L-methionine; via carbonyl

Keyword

3D-structure; Alternative splicing; Complete proteome; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

334 AA

Protein Sequence

MLPCARELPS AAPDSTLLLT AQHWVANLFI LATLIGWTVR SFFLGRMETC CSHLGLRSGR 60
RFAVSIGYWH DPYIQHFVRL SKERKAPEIN RGYFARVHGV SQLIKAFLRK TECHCQIVNL 120
GAGMDTTFWR LKDEDLLPSK YFEVDFPMIV TRKLHSIKCK PPLSSPILEL HSEDTLQMDG 180
HILDSKRYAV IGADLRDLSE LEEKLKKCNM NTQLPTLLIA ECVLVYMTPE QSANLLKWAA 240
NSFERAMFIN YEQVNMGDRF GQIMIENLRR RQCDLAGVET CKSLESQKER LLSNGWETAS 300
AVDMMELYNR LPRAEVSRIE SLEFLDEMEL LEQLMRHYCL CWATKGGNEL GLKEITY 357

Gene Ontology

GO:0003880; F:protein C-terminal carboxyl O-methyltransferase activity; IDA:MGI.
GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; TAS:ProtInc.
GO:0031333; P:negative regulation of protein complex assembly; IMP:MGI.
GO:0042981; P:regulation of apoptotic process; IMP:MGI.
GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; IMP:MGI.

Interpro

IPR007213; LCM_MeTrfase.
IPR021121; LCM_MeTrfase_euk.
IPR016651; Leu_CO_MeTrfase_LCTM1.

Pfam

PF04072; LCM

SMART

PROSITE

PRINTS