UniProt Accession

 ADT3_HUMAN; P12236; Q96C49 

Genbank Protein ID

 AY007135; BC007295; BC007850; BC008737; BC008935; BC014775; BC031912; J03592 

Genbank Nucleotide ID

 AAG01998.1; AAH07295.1; AAH07850.1; AAH08737.1; AAH08935.1; AAH14775.1; AAH31912.1; AAA36750.1 

Protein Name

 ADP/ATP translocase 3 

Protein Synonyms/Alias

 ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6 

Gene Name

 SLC25A6 

Gene Synonyms/Alias

 ANT3; CDABP0051 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	EQAISFAKDFLAGGI	ubiquitination	[1]
23	GIAAAISKTAVAPIE	acetylation	[2]
23	GIAAAISKTAVAPIE	ubiquitination	[1]
43	LQVQHASKQIAADKQ	ubiquitination	[1, 3]
96	FAFKDKYKQIFLGGV	ubiquitination	[1]
105	IFLGGVDKHTQFWRY	acetylation	[2]
105	IFLGGVDKHTQFWRY	ubiquitination	[1, 4]
147	RLAADVGKSGTEREF	ubiquitination	[1, 3, 4]
163	GLGDCLVKITKSDGI	ubiquitination	[1, 5]
166	DCLVKITKSDGIRGL	ubiquitination	[1]
199	FGVYDTAKGMLPDPK	ubiquitination	[3]
268	IFRDEGGKAFFKGAW	acetylation	[2, 6]
268	IFRDEGGKAFFKGAW	ubiquitination	[1]
272	EGGKAFFKGAWSNVL	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. 

Sequence Annotation

 REPEAT 6 98 Solcar 1.
 REPEAT 111 201 Solcar 2.
 REPEAT 212 297 Solcar 3.
 MOTIF 235 240 Substrate recognition (By similarity).
 BINDING 80 80 Nucleotide (By similarity).
 MOD_RES 2 2 N-acetylthreonine.
 MOD_RES 105 105 N6-acetyllysine.
 MOD_RES 268 268 N6-acetyllysine.  

Keyword

 Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Host-virus interaction; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; TAS:UniProtKB.
 GO:0005471; F:ATP:ADP antiporter activity; NAS:UniProtKB.
 GO:0046732; P:active induction of host immune response by virus; TAS:Reactome.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome.
 GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0019058; P:viral infectious cycle; TAS:Reactome. 

Interpro

 IPR002113; Aden_trnslctor.
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF00153; Mito_carr 

SMART

  

PROSITE

 PS50920; SOLCAR 

PRINTS

 PR00927; ADPTRNSLCASE.
 PR00926; MITOCARRIER.