CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin GLE1 
Protein Synonyms/Alias
 cDNA FLJ10905 fis, clone OVARC1000014, highly similar to Nucleoporin GLE1 
Gene Name
 GLE1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19EQHKALLKVDLAAFQubiquitination[1]
107QQGPEAHKEPPAPSQubiquitination[1, 2]
119PSQGPGGKQNEDLQVubiquitination[1, 2]
165DSQAKKIKMDLQKAAubiquitination[1]
170KIKMDLQKAATIPVSubiquitination[1, 2]
188TIAGSKLKEIFDKIHubiquitination[1]
201IHSLLSGKPVQSGGRubiquitination[1, 2]
225GLDFVQYKLAEKFVKubiquitination[1, 2]
229VQYKLAEKFVKQGEEubiquitination[1]
232KLAEKFVKQGEEEVAubiquitination[1]
272LILAHLHKKCPYSVPubiquitination[2, 3]
273ILAHLHKKCPYSVPFubiquitination[1]
285VPFYPTFKEGMALEDubiquitination[1, 4]
302RMLGYQVKDSKVEQQubiquitination[1, 2]
305GYQVKDSKVEQQDNFubiquitination[1, 2, 5]
314EQQDNFLKRMSGMIRubiquitination[1, 2]
418MGSFIRLKQFLEKCLubiquitination[1, 2]
423RLKQFLEKCLQHKDIubiquitination[1]
428LEKCLQHKDIPVPKGubiquitination[1]
434HKDIPVPKGFLTSSFubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 444 AA 
Protein Sequence
MLQLSQQLDA SEQHKALLKV DLAAFQTRGN QLCSLISGII RASSESSYPT AESQAEAERA 60
LREMRDLLMN LGQEITRACE DKRRQDEEEA QVKLQEAQMQ QGPEAHKEPP APSQGPGGKQ 120
NEDLQVKVQD ITMQWYQQLQ DASMQCVLTF EGLTNSKDSQ AKKIKMDLQK AATIPVSQIS 180
TIAGSKLKEI FDKIHSLLSG KPVQSGGRSV SVTLNPQGLD FVQYKLAEKF VKQGEEEVAS 240
HHEAAFPIAV VASGIWELHP RVGDLILAHL HKKCPYSVPF YPTFKEGMAL EDYQRMLGYQ 300
VKDSKVEQQD NFLKRMSGMI RLYAAIIQLR WPYGNRQEIH PHGLNHGWRW LAQILNMEPL 360
SDVTATLLFD FLEVCGNALM KQYQVQFWKM LILIKEDYFP RIEAITSSGQ MGSFIRLKQF 420
LEKCLQHKDI PVPKGFLTSS FWRS 444 
Gene Ontology
 GO:0005643; C:nuclear pore; IEA:InterPro.
 GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro. 
Interpro
 IPR012476; GLE1. 
Pfam
 PF07817; GLE1 
SMART
  
PROSITE
  
PRINTS