| Tag | Content |
|---|
| CPLM ID | CPLM-004885 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium-transporting ATPase alpha chain 1 |
Protein Synonyms/Alias | Gastric H(+)/K(+) ATPase subunit alpha; Proton pump |
Gene Name | ATP4A |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 30 | AAKMSKKKKAGGGGG | methylation | [1] |
|
Reference | [1] A method for the comprehensive proteomic analysis of membrane proteins. Wu CC, MacCoss MJ, Howell KE, Yates JR 3rd. Nat Biotechnol. 2003 May;21(5):532-8. [ PMID: 12692561] |
Functional Description | Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. |
Sequence Annotation | ACT_SITE 387 387 4-aspartylphosphate intermediate (By
METAL 728 728 Magnesium (By similarity).
METAL 732 732 Magnesium (By similarity).
MOD_RES 7 7 Phosphotyrosine (By similarity).
MOD_RES 10 10 Phosphotyrosine (By similarity).
MOD_RES 954 954 Phosphoserine; by PKA (By similarity). |
Keyword | ATP-binding; Cell membrane; Complete proteome; Hydrogen ion transport; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1035 AA |
Protein Sequence | MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM EINDHQLSVA 60
ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY VKFARQLAGG LQCLMWVAAA 120
ICLIAFAIQA SEGDLTTDDN LYLAIALIAV VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA 180
TVIRDGDKFQ INADQLVVGD LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP 240
ECTHESPLET RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 300
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT VTVCLSLTAK 360
RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS HLWFDNHIHT ADTTEDQSGQ 420
TFDQSSETWR ALCRVLTLCN RAAFKSGQDA VPVPKRIVIG DASETALLKF SELTLGNAMG 480
YRDRFPKVCE IPFNSTNKFQ LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP 540
LDEQWREAFQ TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV 600
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE TVEDIAARLR 660
VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV FARTSPQQKL VIVESCQRLG 720
AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI LLDDNFASIV TGVEQGRLIF 780
DNLKKSIAYT LTKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES 840
DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ 900
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT RRLSAFQQGF 960
FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPLPYGILI FVYDEIRKLG 1020
VRCCPGSWWD QELYY 1035 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008900; F:hydrogen:potassium-exchanging ATPase activity; TAS:ProtInc. GO:0000287; F:magnesium ion binding; IEA:InterPro. GO:0006754; P:ATP biosynthetic process; IEA:InterPro. GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro. GO:0045851; P:pH reduction; IEA:Compara. GO:0010155; P:regulation of proton transport; IEA:Compara. GO:0042493; P:response to drug; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |