UniProt Accession

 PSMG2_MOUSE; Q9EST4; Q3TII5; Q3UXH7; Q8C1R5; Q91YJ0 

Genbank Protein ID

 AB031387; AK006069; AK077569; AK135578; AK167840; BC016606 

Genbank Nucleotide ID

 BAB11962.1; BAC25130.2; BAC36869.1; BAE22586.1; BAE39861.1; AAH16606.1 

Protein Name

 Proteasome assembly chaperone 2 

Protein Synonyms/Alias

 CD40 ligand-activated specific transcript 3; Tumor necrosis factor superfamily member 5-induced protein 1 

Gene Name

 Psmg2 

Gene Synonyms/Alias

 Clast3; Tnfsf5ip1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
149	LLTPCLQKSVQNKIK	ubiquitination	[1]
165	LNWLEMEKSRCIPEM	ubiquitination	[1]
188	IPGGGITKTLYDESC	acetylation	[2]
188	IPGGGITKTLYDESC	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Chaperone; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 264 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0007094; P:mitotic spindle assembly checkpoint; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0043248; P:proteasome assembly; ISS:UniProtKB. 

Interpro

 IPR019151; Proteasome_assmbl_chaperone_2.
 IPR016562; Proteasome_assmbl_chp_2_euk. 

Pfam

 PF09754; PAC2 

SMART

  

PROSITE

  

PRINTS