| Tag | Content |
|---|
| CPLM ID | CPLM-005490 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Plasma kallikrein |
Protein Synonyms/Alias | Fletcher factor; Kininogenin; Plasma prekallikrein; Plasma kallikrein heavy chain; Plasma kallikrein light chain |
Gene Name | Klkb1 |
Gene Synonyms/Alias | Klk3; Pk |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 459 | LSLSEITKETPSSRI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
Sequence Annotation | DOMAIN 21 104 Apple 1.
DOMAIN 111 194 Apple 2.
DOMAIN 201 284 Apple 3.
DOMAIN 292 375 Apple 4.
DOMAIN 391 626 Peptidase S1.
ACT_SITE 434 434 Charge relay system.
ACT_SITE 483 483 Charge relay system.
ACT_SITE 578 578 Charge relay system.
CARBOHYD 127 127 N-linked (GlcNAc...).
CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).
CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
CARBOHYD 396 396 N-linked (GlcNAc...).
CARBOHYD 494 494 N-linked (GlcNAc...).
DISULFID 21 104 By similarity.
DISULFID 47 77 By similarity.
DISULFID 51 57 By similarity.
DISULFID 111 194 By similarity.
DISULFID 137 166 By similarity.
DISULFID 141 147 By similarity.
DISULFID 201 284 By similarity.
DISULFID 227 256 By similarity.
DISULFID 231 237 By similarity.
DISULFID 292 375 By similarity.
DISULFID 318 347 By similarity.
DISULFID 322 328 By similarity.
DISULFID 340 345 By similarity.
DISULFID 383 503 By similarity.
DISULFID 419 435 By similarity.
DISULFID 517 584 By similarity.
DISULFID 548 563 By similarity.
DISULFID 574 602 By similarity. |
Keyword | Blood coagulation; Complete proteome; Direct protein sequencing; Disulfide bond; Fibrinolysis; Glycoprotein; Hemostasis; Hydrolase; Inflammatory response; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 638 AA |
Protein Sequence | MILFNRVGYF VSLFATVSCG CMTQLYKNTF FRGGDLAAIY TPDAQYCQKM CTFHPRCLLF 60
SFLAVTPPKE TNKRFGCFMK ESITGTLPRI HRTGAISGHS LKQCGHQISA CHRDIYKGLD 120
MRGSNFNISK TDNIEECQKL CTNNFHCQFF TYATSAFYRP EYRKKCLLKH SASGTPTSIK 180
SADNLVSGFS LKSCALSEIG CPMDIFQHSA FADLNVSQVI TPDAFVCRTI CTFHPNCLFF 240
TFYTNEWETE SQRNVCFLKT SKSGRPSPPI PQENAISGYS LLTCRKTRPE PCHSKIYSGV 300
DFEGEELNVT FVQGADVCQE TCTKTIRCQF FIYSLLPQDC KEEGCKCSLR LSTDGSPTRI 360
TYGMQGSSGY SLRLCKLVDS PDCTTKINAR IVGGTNASLG EWPWQVSLQV KLVSQTHLCG 420
GSIIGRQWVL TAAHCFDGIP YPDVWRIYGG ILSLSEITKE TPSSRIKELI IHQEYKVSEG 480
NYDIALIKLQ TPLNYTEFQK PICLPSKADT NTIYTNCWVT GWGYTKEQGE TQNILQKATI 540
PLVPNEECQK KYRDYVINKQ MICAGYKEGG TDACKGDSGG PLVCKHSGRW QLVGITSWGE 600
GCARKDQPGV YTKVSEYMDW ILEKTQSSDV RALETSSA 638 |
Gene Ontology | GO:0005615; C:extracellular space; IEA:Compara. GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. GO:0007596; P:blood coagulation; IEA:UniProtKB-KW. GO:0042730; P:fibrinolysis; IEA:UniProtKB-KW. GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. GO:0031639; P:plasminogen activation; IEA:Compara. GO:0051919; P:positive regulation of fibrinolysis; IEA:Compara. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |