CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028182
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydrolipoyl dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 CG7430, Dmel_CG7430 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
104AHSGDLEKRGISCGSacetylation[1]
139GGIAMLFKKNKVTQLacetylation[1]
259EVSKTFQKVLTKQGLacetylation[1]
263TFQKVLTKQGLKFKLacetylation[1]
267VLTKQGLKFKLGTKVacetylation[1]
405GKSEEQLKQEGVAYKacetylation[1]
415GVAYKVGKFPFLANSacetylation[1]
500NVAAAFGKPINF***acetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; NAD; Oxidoreductase; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MQFTLRHVVS AVAKTPLRTN AAILGALNAR CYSSTHEADI VVIGSGPGGY VAAIKAAQMG 60
MKTVSVEKEA TLGGTCLNVG CIPSKALLNN SHYYHMAHSG DLEKRGISCG SVSLDLEKLM 120
GQKSNAVKAL TGGIAMLFKK NKVTQLTGFG TIVNPNEVEV KKSDGSTETV KTKNILIATG 180
SEVTPFPGIE IDEEVIVSST GALKLAKVPK HLVVIGAGVI GLELGSVWSR LGAEVTAIEF 240
MDTIGGVGID NEVSKTFQKV LTKQGLKFKL GTKVTAASRS GDNVTVSVEN AKSGEKEEIQ 300
CDALLVSVGR RPYTEGLGLE AVGIVKDDRG RIPVNATFQT VVPNIYAIGD CIHGPMLAHK 360
AEDEGLITIE GINGGHVHID YNCVPSVVYT HPEVAWVGKS EEQLKQEGVA YKVGKFPFLA 420
NSRAKTNNDT DGFVKVLADQ ATDKILGTHI IGPGAGELIN EAVLAMEYGA AAEDVARVCH 480
AHPTCSEALR EANVAAAFGK PINF 504 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0004148; F:dihydrolipoyl dehydrogenase activity; IEA:EC.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR006258; Lipoamide_DH.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.