CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038847
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 
Protein Synonyms/Alias
 Phosphodiesterase 1C, isoform CRA_a 
Gene Name
 Pde1c 
Gene Synonyms/Alias
 rCG_52512 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
587RWRAKVPKEEKAKKEacetylation[1]
590AKVPKEEKAKKEAEEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 768 AA 
Protein Sequence
MTDTSHKKEG FKKCRSATFS IDGYSFTIVA NEAGDKNARP LARFSRSKSQ NCLWNSLIDG 60
LTGNVKEKPR PTIVQDTRPP EEILADELPQ LDSPEALVKT SFRLRSLVKQ LERGEASVVD 120
LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS EVRDWLASTF TRQMGMMLRR 180
SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM VGLSYPPAVI DALKDVDTWS FDVFSLNEAS 240
GDHALKFIFY ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV 300
HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH 360
HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK AMKTALQQPE 420
AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR QGDREAELGL PFSPLCDRKS 480
TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSINSSDAKR 540
SGVKSSGSEG SAPINNSVIP VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR 600
LAAEEKQKEM EAKSQAEQGT TSKAEKKTSG ETKGQVNGTR TSKGDNPRGK NSKGDKAGEK 660
QQNGDLKDGK NKADKKDHSN TGNESKKADG TKKRSHGSPA PSTSSTSRLT LPVIKPPLRH 720
FKRPAYASSS YAPSVPKKTD DHPVRYKMLD QRIKMKKIQN ISHHWNKK 768 
Gene Ontology
 GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS.
 IPR013706; PDEase_N. 
Pfam
 PF00233; PDEase_I
 PF08499; PDEase_I_N 
SMART
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.