UniProt Accession

 E5RFF9_HUMAN; E5RFF9 

Genbank Protein ID

 AC009630 

Genbank Nucleotide ID

  

Protein Name

 DNA replication complex GINS protein SLD5 

Protein Synonyms/Alias

  

Gene Name

 GINS4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
102	CRLMKIEKFFPHVLE	ubiquitination	[1]
110	FFPHVLEKEKTRPEG	ubiquitination	[1]
112	PHVLEKEKTRPEGEP	ubiquitination	[1]
142	ANTESYLKNVALKHM	ubiquitination	[1]
164	DLFRAVPKPDLDSYV	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; DNA replication; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 

Interpro

 IPR021151; GINS_complex.
 IPR008591; GINS_Sld5. 

Pfam

 PF05916; Sld5 

SMART

  

PROSITE

  

PRINTS