CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023039
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box/LRR-repeat protein 7 
Protein Synonyms/Alias
 F-box and leucine-rich repeat protein 7; F-box protein FBL6/FBL7 
Gene Name
 FBXL7 
Gene Synonyms/Alias
 FBL6; FBL7; KIAA0840 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
263LTREASIKLSPLHGKacetylation[1]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 
Functional Description
 Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest (By similarity). 
Sequence Annotation
 DOMAIN 111 157 F-box.
 REPEAT 170 195 LRR 1.
 REPEAT 196 221 LRR 2.
 REPEAT 222 247 LRR 3.
 REPEAT 253 281 LRR 4.
 REPEAT 282 307 LRR 5.
 REPEAT 308 333 LRR 6.
 REPEAT 334 359 LRR 7.
 REPEAT 360 385 LRR 8.
 REPEAT 386 411 LRR 9.
 REPEAT 412 437 LRR 10.
 REPEAT 438 463 LRR 11.  
Keyword
 Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Mitosis; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
MGANNGKQYG SEGKGSSSIS SDVSSSTDHT PTKAQKNVAT SEDSDLSMRT LSTPSPALIC 60
PPNLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL IRLASRPQKE QASIDRLPDH 120
SMVQIFSFLP TNQLCRCARV CRRWYNLAWD PRLWRTIRLT GETINVDRAL KVLTRRLCQD 180
TPNVCLMLET VTVSGCRRLT DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL 240
EHLDVSGCSK VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL 300
THLYLRRCVR LTDEGLRYLV IYCASIKELS VSDCRFVSDF GLREIAKLES RLRYLSIAHC 360
GRVTDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN CTKLKSLDIG KCPLVSDTGL 420
ECLALNCFNL KRLSLKSCES ITGQGLQIVA ANCFDLQTLN VQDCEVSVEA LRFVKRHCKR 480
CVIEHTNPAF F 491 
Gene Ontology
 GO:0005813; C:centrosome; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; ISS:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.
 GO:0007067; P:mitosis; ISS:UniProtKB.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. 
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR006553; Leu-rich_rpt_Cys-con_subtyp. 
Pfam
 PF00646; F-box 
SMART
 SM00256; FBOX
 SM00367; LRR_CC 
PROSITE
 PS50181; FBOX
 PS51450; LRR 
PRINTS