CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029124
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Putative Polycomb group protein ASXL1 
Protein Synonyms/Alias
  
Gene Name
 ASXL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
346EKKVEQWKEKFFEDYubiquitination[1, 2, 3, 4, 5]
348KVEQWKEKFFEDYYGubiquitination[3, 4]
357FEDYYGQKLGLTKEEubiquitination[5, 6]
362GQKLGLTKEESLQQNubiquitination[1, 4]
1366VGSVKNEKTFVGGPLubiquitination[4]
1374TFVGGPLKANAENRKubiquitination[4, 5]
1414KLPREPGKGLSEPLEubiquitination[4, 5]
1432LPSQLSIKQAFYGKLubiquitination[1, 2, 4, 5]
1438IKQAFYGKLSKLQLSubiquitination[4]
1441AFYGKLSKLQLSSTSubiquitination[2, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1536 AA 
Protein Sequence
MGVVNFVFRA SEDLQVLENY SDAPMTPKQI LQVIEAEGLK EMSGTSPLAC LNAMLHSNSR 60
GGEGLFYKLP GRISLFTLKK DALQWSRHPA TVEGEEPEDT ADVESCGSNE ASTVSGENDV 120
SLDETSSNAS CSTESQSRPL SNPRDSYRAS SQANKQKKKT GVMLPRVVLT PLKVNGAHVE 180
SASGFSGCHA DGESGSPSSS SSGSLALGSA AIRGQAEVTQ DPAPLLRGFR KPATGQMKRN 240
RGEEIDFETP GSILVNTNLR ALINSRTFHA LPSHFQQQLL FLLPEVDRQV GTDGLLRLSS 300
SALNNEFFTH AAQSWRERLA DGEFTHEMQV RIRQEMEKEK KVEQWKEKFF EDYYGQKLGL 360
TKEESLQQNV GQEEAEIKSG LCVPGESVRI QRGPATRQRD GHFKKRSRPD LRTRARRNLY 420
KKQESEQAGV AKDAKSVASD VPLYKDGEAK TDPAGLSSPH LPGTSSAAPD LEGPEFPVES 480
VASRIQAEPD NLARASASPD RIPSLPQETV DQEPKDQKRK SFEQAASASF PEKKPRLEDR 540
QSFRNTIESV HTEKPQPTKE EPKVPPIRIQ LSRIKPPWVV KGQPTYQICP RIIPTTESSC 600
RGWTGARTLA DIKARALQVR GARGHHCHRE AATTAIGGGG GPGGGGGGAT DEGGGRGSSS 660
GDGGEACGHP EPRGGPSTPG KCTSDLQRTQ LLPPYPLNGE HTQAGTAMSR ARREDLPSLR 720
KEESCLLQRA TVGLTDGLGD ASQLPVAPTG DQPCQALPLL SSQTSVAERL VEQPQLHPDV 780
RTECESGTTS WESDDEEQGP TVPADNGPIL SLVGDDTLEK GTGQALDSHP TMKDPVNVTP 840
SSTPESSPTD CLQNRAFDDE LGLGGSCPPM RESDTRQENL KTKALVSNSS LHWIPIPSND 900
EVVKQPKPES REHIPSVEPQ VGEEWEKAAP TPPALPGDLT AEEGLDPLDS LTSLWTVPSR 960
GGSDSNGSYC QQVDIEKLKI NGDSEALSPH GESTDTASDF EGHLTEDSSE ADTREAAVTK 1020
GSSVDKDEKP NWNQSAPLSK VNGDMRLVTR TDGMVAPQSW VSRVCAVRQK IPDSLLLAST 1080
EYQPRAVCLS MPGSSVEATN PLVMQLLQGS LPLEKVLPPA HDDSMSESPQ VPLTKDQSHG 1140
SLRMGSLHGL GKNSGMVDGS SPSSLRALKE PLLPDSCETG TGLARIEATQ APGAPQKNCK 1200
AVPSFDSLHP VTNPITSSRK LEEMDSKEQF SSFSCEDQKE VRAMSQDSNS NAAPGKSPGD 1260
LTTSRTPRFS SPNVISFGPE QTGRALGDQS NVTGQGKKLF GSGNVAATLQ RPRPADPMPL 1320
PAEIPPVFPS GKLGPSTNSM SGGVQTPRED WAPKPHAFVG SVKNEKTFVG GPLKANAENR 1380
KATGHSPLEL VGHLEGMPFV MDLPFWKLPR EPGKGLSEPL EPSSLPSQLS IKQAFYGKLS 1440
KLQLSSTSFN YSSSSPTFPK GLAGSVVQLS HKANFGASHS ASLSLQMFTD SSTVESISLQ 1500
CACSLKAMIM CQGCGAFCHD DCIGPSKLCV LCLVVR 1536 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR026905; ASX-like_PHD.
 IPR024811; ASX/ASX-like.
 IPR024815; ASXL1. 
Pfam
 PF13922; PHD_3 
SMART
  
PROSITE
  
PRINTS