CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000080
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol 3-kinase regulatory subunit beta 
Protein Synonyms/Alias
 PI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PI3-kinase subunit p85-beta; PtdIns-3-kinase regulatory subunit p85-beta 
Gene Name
 PIK3R2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
343SREEVNEKLRDTPDGubiquitination[1]
477TSQELQMKRTAIEAFubiquitination[1]
639AEEMLSGKRDGTFLIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. 
Sequence Annotation
 DOMAIN 4 80 SH3.
 DOMAIN 109 295 Rho-GAP.
 DOMAIN 330 425 SH2 1.
 DOMAIN 622 716 SH2 2.
 MOD_RES 464 464 Phosphotyrosine.
 MOD_RES 605 605 Phosphotyrosine.  
Keyword
 3D-structure; Complete proteome; Disease mutation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH2 domain; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 728 AA 
Protein Sequence
MAGPEGFQYR ALYPFRRERP EDLELLPGDV LVVSRAALQA LGVAEGGERC PQSVGWMPGL 60
NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP RDGAPEPGLT LPDLPEQFSP 120
PDVAPPLLVK LVEAIERTGL DSESHYRPEL PAPRTDWSLS DVDQWDTAAL ADGIKSFLLA 180
LPAPLVTPEA SAEARRALRE AAGPVGPALE PPTLPLHRAL TLRFLLQHLG RVASRAPALG 240
PAVRALGATF GPLLLRAPPP PSSPPPGGAP DGSEPSPDFP ALLVEKLLQE HLEEQEVAPP 300
ALPPKPPKAK PASTVLANGG SPPSLQDAEW YWGDISREEV NEKLRDTPDG TFLVRDASSK 360
IQGEYTLTLR KGGNNKLIKV FHRDGHYGFS EPLTFCSVVD LINHYRHESL AQYNAKLDTR 420
LLYPVSKYQQ DQIVKEDSVE AVGAQLKVYH QQYQDKSREY DQLYEEYTRT SQELQMKRTA 480
IEAFNETIKI FEEQGQTQEK CSKEYLERFR REGNEKEMQR ILLNSERLKS RIAEIHESRT 540
KLEQQLRAQA SDNREIDKRM NSLKPDLMQL RKIRDQYLVW LTQKGARQKK INEWLGIKNE 600
TEDQYALMED EDDLPHHEER TWYVGKINRT QAEEMLSGKR DGTFLIRESS QRGCYACSVV 660
VDGDTKHCVI YRTATGFGFA EPYNLYGSLK ELVLHYQHAS LVQHNDALTV TLAHPVRAPG 720
PGPPPAAR 728 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:InterPro.
 GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; IEA:InterPro.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; ISS:GOC.
 GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
 GO:0043551; P:regulation of phosphatidylinositol 3-kinase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR001720; PI3kinase_P85.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR000980; SH2.
 IPR001452; SH3_domain. 
Pfam
 PF00620; RhoGAP
 PF00017; SH2 
SMART
 SM00324; RhoGAP
 SM00252; SH2
 SM00326; SH3 
PROSITE
 PS50238; RHOGAP
 PS50001; SH2
 PS50002; SH3 
PRINTS
 PR00678; PI3KINASEP85.
 PR00401; SH2DOMAIN.