| Tag | Content |
|---|
| CPLM ID | CPLM-023088 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glucocorticoid modulatory element-binding protein 2 |
Protein Synonyms/Alias | GMEB-2; DNA-binding protein p79PIF; Parvovirus initiation factor p79; PIF p79 |
Gene Name | GMEB2 |
Gene Synonyms/Alias | KIAA1269 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 116 | VCPGINVKCVQYDEH | ubiquitination | [1] | | 155 | MNGIMLRKIMDSGEL | ubiquitination | [1] | | 169 | LDFYQHDKVCSNTCR | ubiquitination | [1] | | 296 | GMLDLVKKVLASHKC | ubiquitination | [1] | | 302 | KKVLASHKCQMDRSR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
Sequence Annotation | DOMAIN 81 163 SAND.
METAL 110 110 Zinc (By similarity).
METAL 167 167 Zinc (By similarity).
METAL 171 171 Zinc (By similarity).
METAL 175 175 Zinc (By similarity).
BINDING 136 136 DNA (By similarity).
BINDING 140 140 DNA (By similarity).
BINDING 143 143 DNA (By similarity).
BINDING 154 154 DNA (By similarity).
MOD_RES 373 373 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 530 AA |
Protein Sequence | MATPDVSVHM EEVVVVTTPD TAVDGSGVEG VKTVLVTTNL APHGGDLTED NMETENAAAA 60
AAAAFTASSQ LKEAVLVKMA EEGENLEAEI VYPITCGDSR ANLIWRKFVC PGINVKCVQY 120
DEHVISPKEF VHLAGKSTLK DWKRAIRMNG IMLRKIMDSG ELDFYQHDKV CSNTCRSTKI 180
DLSGARVSLS SPTSAEYIPL TPAAADVNGS PATITIETCE DPGDWTAAIG DDTFTFWRGL 240
KDAGLLDEVI QEFHQELVET MRGLQQRVQD PPLQLRDAVL LNNIVQNFGM LDLVKKVLAS 300
HKCQMDRSRE QYARDLAALE QQCDEHRRRA KELKHKSQHL SNVLMTLTPV SLPPPVKRPR 360
LARATSGPAA MASQVLTQSA QLALGPGVPV PQLTSVPLGK VVSTLPSTVL GKGSLQAPPA 420
SSPASPLLGG YTVLASSGST YPSTVEIHPD ASSLTVLSTA AVQDGSTVFK VVSPLQLLTL 480
PGLGPTLQNV AQASPGSSTI VTVPAGAAPG PEEHTATIEV AAMAEDHERK 530 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005634; C:nucleus; IDA:HPA. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0003713; F:transcription coactivator activity; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |