CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010158
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Phenylalanine--tRNA ligase alpha subunit 
Protein Synonyms/Alias
 Phenylalanyl-tRNA synthetase alpha subunit; PheRS 
Gene Name
 pheS 
Gene Synonyms/Alias
 MPN_105; MP049 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
37SFRNADLKPLLSQIKacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
  
Sequence Annotation
 METAL 254 254 Magnesium (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MIDQSKLIER WKTTFETAQN PTELLAFKNS FRNADLKPLL SQIKETTDIE TKRHLGQLYK 60
QLESTLQTLH DTQLQVFTQA QSSSVLTHGD VMLLATSFAP GSSNIIYQVI DELVNYFKKF 120
LFTVNYDSEL TTIADCFDLL NIPKDHPSRN LTDTFYLDKN RLLRTHCTAA TLRAVKETKK 180
SNNPDIRIAS FGAVFRKDDD DATHSHQFNQ LDFMWIKKDF SLTNLKWFMQ NMINHIFGEN 240
TSARFRLSHF PFTEPSFEID IRCWLCQNGC GVCKKTRWIE VLGAGILHPQ VMANMGFSDT 300
DNIRGIAAGI GIERLVMLKH GISDIRDLYD NNFKFLAQFT D 341 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:HAMAP.
 GO:0000049; F:tRNA binding; IEA:InterPro.
 GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR006195; aa-tRNA-synth_II.
 IPR004529; Phe-tRNA-synth_IIc_asu.
 IPR022911; Phe_tRNA_ligase_alpha1_bac.
 IPR002319; Phenylalanyl-tRNA_Synthase. 
Pfam
 PF01409; tRNA-synt_2d 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS