CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033001
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Activated CDC42 kinase 1 
Protein Synonyms/Alias
  
Gene Name
 TNK2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
163KDLRLLEKLGDGSFGubiquitination[1]
1013RPRGECHKVLEMFDWubiquitination[2]
1039SWGPAHHKR******ubiquitination[2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1040 AA 
Protein Sequence
MPAARRFPGL ELSFPLLARL RRRLYTRLGG GRMQPEEGTG WLLELLSEVQ LQQYFLRLRD 60
DLNVTRLSHF EYVKNEDLEK IGMGRPGQRR LWEAVKRRKA LCKRKSWMSK VFSGKRLEAE 120
FPPHHSQSTF RKTSPAPGGP AGEGPLQSLT CLIGEKDLRL LEKLGDGSFG VVRRGEWDAP 180
SGKTVSVAVK CLKPDVLSQP EAMDDFIREV NAMHSLDHRN LIRLYGVVLT PPMKMVTELA 240
PLGSLLDRLR KHQGHFLLGT LSRYAVQVAE GMGYLESKRF IHRDLAARNL LLATRDLVKI 300
GDFGLMRALP QNDDHYVMQE HRKVPFAWCA PESLKTRTFS HASDTWMFGV TLWEMFTYGQ 360
EPWIGLNGSQ ILHKIDKEGE RLPRPEDCPQ DIYNVMVQCW AHKPEDRPTF VALRDFLLEA 420
QPTDMRALQD FEEPDKLHIQ MNDVITVIEG RAENYWWRGQ NTRTLCVGPF PRNVVTSVAG 480
LSAQDISQPL QNSFIHTGHG DSDPRHCWGF PDRIDELYLG NPMDPPDLLS VELSTSRPPQ 540
HLGGVKKPTY DPVSEDQDPL SSDFKRLGLR KPGLPRGLWL AKPSARVPGT KASRGSGAEV 600
TLIDFGEEPV VPALRPCAPS LAQLAMDACS LLDETPPQSP TRALPRPLHP TPVVDWDARP 660
LPPPPAYDDV AQDEDDFEIC SINSTLVGAG VPAGPSQGQT NYAFVPEQAR PPPPLEDNLF 720
LPPQGGGKPP SSAQTAEIFQ ALQQECMRQL QAPAGSPAPS PSPGGDDKPQ VPPRVPIPPR 780
PTRPHVQLSP APPGEEETSQ WPGPASPPRV PPREPLSPQG SRTPSPLVPP GSSPLPPRLS 840
SSPGKTMPTT QSFASDPKYA TPQVIQAPGP RAGPCILPIV RDGKKVSSTH YYLLPERPSY 900
LERYQRFLRE AQSPEEPTPL PVPLLLPPPS TPAPAAPTAT VRPMPQAALD PKANFSTNNS 960
NPGARPPPPR ATARLPQRGC PGDGPEAGRP ADKIQMVEQL FGLGLRPRGE CHKVLEMFDW 1020
NLEQAGCHLL GSWGPAHHKR 1040 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR015116; Cdc42_binding_dom_like.
 IPR021619; Inhibitor_Mig-6.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR001452; SH3_domain.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF09027; GTPase_binding
 PF11555; Inhibitor_Mig-6
 PF07714; Pkinase_Tyr 
SMART
 SM00326; SH3
 SM00219; TyrKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS50002; SH3 
PRINTS
 PR00109; TYRKINASE.