CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositide phosphatase SAC1 
Protein Synonyms/Alias
 Suppressor of actin mutations 1-like protein 
Gene Name
 Sacm1l 
Gene Synonyms/Alias
 Kiaa0851; Sac1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
101DFDVLSYKKTMLHLTubiquitination[1]
432EEQDEFEKTYKNAWAubiquitination[1]
435DEFEKTYKNAWADNAubiquitination[1]
456YAGTGALKTDFTRTGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity). 
Sequence Annotation
 DOMAIN 122 451 SAC.
 MOD_RES 456 456 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 587 AA 
Protein Sequence
MAAAAYEHLK LHITPEKFYV EACDDGADDV LIIDRVSTEV TLAVKKDVPP SAVTRPIFGI 60
LGTIHLVAGN YLVVITKKMK VGECFNHAVW RATDFDVLSY KKTMLHLTDI QLQDNKTFLA 120
MLNHVLSMDG FYFSTTYDLT HTLQRLSNTS PEFQEMSLLE RADQRFVWNG HLLRELSAQP 180
EVHRFALPVL HGFITMHSCS INGKYFDWIL ISRRSCFRAG VRYYVRGIDS EGHAANFVET 240
EQIVHYSGNR ASFVQTRGSI PIFWSQRPNL KYKPHPQISK VANHMDGFQR HFDSQVIIYG 300
KQVIINLVNH KGSEKPLEQT FANMVSSLGS GMIRYIAFDF HKECKNMRWD RLSILLDQVA 360
EMQDELSYFL VDSAGKVVTN QDGVFRSNCM DCLDRTNVIQ SLLARRSLQA QLQRLGVLHV 420
GQKLEEQDEF EKTYKNAWAD NANACAKQYA GTGALKTDFT RTGKRTQLGL LMDGFNSLLR 480
YYKNNFSDGF RQDSIDLFLG NYSVDELESH SPLSVPRDWK FLALPIIMVV AFSMCIICLL 540
MAGDTWTETL AYVLFWGVAS IGTFFIILYN GKDFVDAPRL VQKEKID 587 
Gene Ontology
 GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; IDA:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:Compara.
 GO:0016791; F:phosphatase activity; ISS:UniProtKB.
 GO:0034593; F:phosphatidylinositol bisphosphate phosphatase activity; IEA:Compara.
 GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:Compara.
 GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IEA:Compara.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:Compara. 
Interpro
 IPR002013; Syja_N. 
Pfam
 PF02383; Syja_N 
SMART
  
PROSITE
 PS50275; SAC 
PRINTS