CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012601
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thyroid receptor-interacting protein 11 
Protein Synonyms/Alias
 TR-interacting protein 11; TRIP-11; Clonal evolution-related gene on chromosome 14 protein; Golgi-associated microtubule-binding protein 210; GMAP-210; Trip230 
Gene Name
 TRIP11 
Gene Synonyms/Alias
 CEV14 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
419SLAEDNLKLKMRIEVubiquitination[1]
738RLLEEANKYEKTIEEubiquitination[1]
998SDIFQETKVQSLNIEubiquitination[1]
1504EFECHSMKEKALAFEacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. 
Sequence Annotation
 DOMAIN 1774 1823 GRIP.
 MOD_RES 464 464 Phosphoserine.
 MOD_RES 1842 1842 Phosphoserine.
 MOD_RES 1846 1846 Phosphothreonine.
 MOD_RES 1891 1891 Phosphoserine.  
Keyword
 Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dwarfism; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1979 AA 
Protein Sequence
MSSWLGGLGS GLGQSLGQVG GSLASLTGQI SNFTKDMLME GTEEVEAELP DSRTKEIEAI 60
HAILRSENER LKKLCTDLEE KHEASEIQIK QQSTSYRNQL QQKEVEISHL KARQIALQDQ 120
LLKLQSAAQS VPSGAGVPAT TASSSFAYGI SHHPSAFHDD DMDFGDIISS QQEINRLSNE 180
VSRLESEVGH WRHIAQTSKA QGTDNSDQSE ICKLQNIIKE LKQNRSQEID DHQHEMSVLQ 240
NAHQQKLTEI SRRHREELSD YEERIEELEN LLQQGGSGVI ETDLSKIYEM QKTIQVLQIE 300
KVESTKKMEQ LEDKIKDINK KLSSAENDRD ILRREQEQLN VEKRQIMEEC ENLKLECSKL 360
QPSAVKQSDT MTEKERILAQ SASVEEVFRL QQALSDAENE IMRLSSLNQD NSLAEDNLKL 420
KMRIEVLEKE KSLLSQEKEE LQMSLLKLNN EYEVIKSTAT RDISLDSELH DLRLNLEAKE 480
QELNQSISEK ETLIAEIEEL DRQNQEATKH MILIKDQLSK QQNEGDSIIS KLKQDLNDEK 540
KRVHQLEDDK MDITKELDVQ KEKLIQSEVA LNDLHLTKQK LEDKVENLVD QLNKSQESNV 600
SIQKENLELK EHIRQNEEEL SRIRNELMQS LNQDSNSNFK DTLLKEREAE VRNLKQNLSE 660
LEQLNENLKK VAFDVKMENE KLVLACEDVR HQLEECLAGN NQLSLEKNTI VETLKMEKGE 720
IEAELCWAKK RLLEEANKYE KTIEELSNAR NLNTSALQLE HEHLIKLNQK KDMEIAELKK 780
NIEQMDTDHK ETKDVLSSSL EEQKQLTQLI NKKEIFIEKL KERSSKLQEE LDKYSQALRK 840
NEILRQTIEE KDRSLGSMKE ENNHLQEELE RLREEQSRTA PVADPKTLDS VTELASEVSQ 900
LNTIKEHLEE EIKHHQKIIE DQNQSKMQLL QSLQEQKKEM DEFRYQHEQM NATHTQLFLE 960
KDEEIKSLQK TIEQIKTQLH EERQDIQTDN SDIFQETKVQ SLNIENGSEK HDLSKAETER 1020
LVKGIKEREL EIKLLNEKNI SLTKQIDQLS KDEVGKLTQI IQQKDLEIQA LHARISSTSH 1080
TQDVVYLQQQ LQAYAMEREK VFAVLNEKTR ENSHLKTEYH KMMDIVAAKE AALIKLQDEN 1140
KKLSTRFESS GQDMFRETIQ NLSRIIREKD IEIDALSQKC QTLLAVLQTS STGNEAGGVN 1200
SNQFEELLQE RDKLKQQVKK MEEWKQQVMT TVQNMQHESA QLQEELHQLQ AQVLVDSDNN 1260
SKLQVDYTGL IQSYEQNETK LKNFGQELAQ VQHSIGQLCN TKDLLLGKLD IISPQLSSAS 1320
LLTPQSAECL RASKSEVLSE SSELLQQELE ELRKSLQEKD ATIRTLQENN HRLSDSIAAT 1380
SELERKEHEQ TDSEIKQLKE KQDVLQKLLK EKDLLIKAKS DQLLSSNENF TNKVNENELL 1440
RQAVTNLKER ILILEMDIGK LKGENEKIVE TYRGKETEYQ ALQETNMKFS MMLREKEFEC 1500
HSMKEKALAF EQLLKEKEQG KTGELNQLLN AVKSMQEKTV VFQQERDQVM LALKQKQMEN 1560
TALQNEVQRL RDKEFRSNQE LERLRNHLLE SEDSYTREAL AAEDREAKLR KKVTVLEEKL 1620
VSSSNAMENA SHQASVQVES LQEQLNVVSK QRDETALQLS VSQEQVKQYA LSLANLQMVL 1680
EHFQQEEKAM YSAELEKQKQ LIAEWKKNAE NLEGKVISLQ ECLDEANAAL DSASRLTEQL 1740
DVKEEQIEEL KRQNELRQEM LDDVQKKLMS LANSSEGKVD KVLMRNLFIG HFHTPKNQRH 1800
EVLRLMGSIL GVRREEMEQL FHDDQGGVTR WMTGWLGGGS KSVPNTPLRP NQQSVVNSSF 1860
SELFVKFLET ESHPSIPPPK LSVHDMKPLD SPGRRKRDTN APESFKDTAE SRSGRRTDVN 1920
PFLAPRSAAV PLINPAGLGP GGPGHLLLKP ISDVLPTFTP LPALPDNSAG VVLKDLLKQ 1979 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0000042; P:protein targeting to Golgi; IEA:InterPro.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 
Interpro
 IPR000237; GRIP. 
Pfam
  
SMART
  
PROSITE
 PS50913; GRIP 
PRINTS