CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023834
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 451 
Protein Synonyms/Alias
 Coactivator for steroid receptors 
Gene Name
 ZNF451 
Gene Synonyms/Alias
 COASTER; KIAA0576; KIAA1702 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
121ENPLENQKNDQNNSDubiquitination[1]
130DQNNSDTKISETETLubiquitination[2]
240VEEETDYKSPSADDKubiquitination[3]
247KSPSADDKGQPSDPSubiquitination[3]
286EAESCEGKPDCVTSKubiquitination[2, 4, 5]
293KPDCVTSKKRLVPPLubiquitination[4]
294PDCVTSKKRLVPPLHubiquitination[2]
313IATTEVFKDPADCHPubiquitination[2]
333HRVYPVAKDTSPFQPubiquitination[2, 3]
356VEALEHSKRGNTTSPubiquitination[1, 2, 3, 4, 5, 6]
369SPLDSTSKEMEVMGCubiquitination[2]
401YMTQYQRKLWEDMEDubiquitination[2]
473LTKKTQEKISHLPFDubiquitination[1]
490SLFGQDVKAVVAEDNubiquitination[1, 3, 4]
500VAEDNNIKENDYKDHubiquitination[2, 3]
505NIKENDYKDHKYYNQubiquitination[4]
522YFYSHDQKAHYHNRGubiquitination[2]
532YHNRGYSKGDWYKPRubiquitination[2, 5]
537YSKGDWYKPRNHPYRubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
 May be involved in transcriptional regulation. Coactivator for steroid receptors. 
Sequence Annotation
 ZN_FING 169 195 C2H2-type 1.
 ZN_FING 253 277 C2H2-type 2.
 ZN_FING 315 337 C2H2-type 3.
 ZN_FING 362 386 C2H2-type 4.
 ZN_FING 498 521 C2H2-type 5.
 ZN_FING 531 554 C2H2-type 6.
 ZN_FING 606 631 C2H2-type 7; atypical.
 ZN_FING 636 659 C2H2-type 8.
 ZN_FING 667 690 C2H2-type 9.
 ZN_FING 753 776 C2H2-type 10.
 ZN_FING 789 812 C2H2-type 11.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1061 AA 
Protein Sequence
MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS SDDEEPSTSY 60
TDRMPESKVP SSENHRPEMC SSCNVPLPIG DSSSFSGSCS SSPERIVSQT SSVENPLENQ 120
KNDQNNSDTK ISETETLKSS QNFQTLPSSP LLVPQESLAS SEVKENLRID SSSASQHGRD 180
AILYLQTQVA EMSRVIRDLQ SRSCFRFHHS RPSENSSVPW DISTSKEENL STVEEETDYK 240
SPSADDKGQP SDPSQSSFTG LLKRMEQRGV IKRVTLQSEA ESCEGKPDCV TSKKRLVPPL 300
HPLLRIATTE VFKDPADCHP SSFMGHRVYP VAKDTSPFQP NPPAEGPIVE ALEHSKRGNT 360
TSPLDSTSKE MEVMGCRFYH AASIAARAAS YMAYMTQYQR KLWEDMEDLV HDPEFDRGKA 420
RCIISDGMDA GLWQLCTTRD IMDSVVRVMA MAIDYRRQAW LRLTSLTKKT QEKISHLPFD 480
GTSLFGQDVK AVVAEDNNIK ENDYKDHKYY NQHRYFYSHD QKAHYHNRGY SKGDWYKPRN 540
HPYRYRKKGD SPERHGYKN 559 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS