CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007353
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NADPH-dependent 1-acyldihydroxyacetone phosphate reductase 
Protein Synonyms/Alias
 ADR; 1-acyl DHAP reductase; Acyl/alkyl DHAP reductase; Acylglycerone-phosphate reductase 
Gene Name
 AYR1 
Gene Synonyms/Alias
 YIL124W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
226KTMAKDNKPMPADAYubiquitination[1]
239AYAKQLVKDILSTSDubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA). Required for spore germination. 
Sequence Annotation
 NP_BIND 13 37 NAD or NADP (By similarity).
 ACT_SITE 157 157 Proton acceptor (By similarity).
 BINDING 144 144 Substrate (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Lipid droplet; NAD; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 297 AA 
Protein Sequence
MSELQSQPKK IAVVTGASGG IGYEVTKELA RNGYLVYACA RRLEPMAQLA IQFGNDSIKP 60
YKLDISKPEE IVTFSGFLRA NLPDGKLDLL YNNAGQSCTF PALDATDAAV EQCFKVNVFG 120
HINMCRELSE FLIKAKGTIV FTGSLAGVVS FPFGSIYSAS KAAIHQYARG LHLEMKPFNV 180
RVINAITGGV ATDIADKRPL PETSIYNFPE GREAFNSRKT MAKDNKPMPA DAYAKQLVKD 240
ILSTSDPVDV YRGTFANIMR FVMIFVPYWL LEKGLSKKFK LDKVNNALKS KQKNKDD 297 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005811; C:lipid particle; IDA:SGD.
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0000140; F:acylglycerone-phosphate reductase activity; IMP:SGD.
 GO:0006654; P:phosphatidic acid biosynthetic process; IMP:SGD. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.