UniProt Accession

 RU1C_RAT; D3ZCL3 

Genbank Protein ID

 CH473988 

Genbank Nucleotide ID

 EDL96903.1 

Protein Name

 U1 small nuclear ribonucleoprotein C 

Protein Synonyms/Alias

 U1 snRNP C; U1-C; U1C 

Gene Name

 Snrpc 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
35	RKHKENVKDYYQKWM	acetylation	[1]
52	QAQSLIDKTTAAFQQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). 

Sequence Annotation

 ZN_FING 4 36 Matrin-type.
 MOD_RES 8 8 Phosphotyrosine (By similarity).
 MOD_RES 17 17 Phosphoserine (By similarity).
 MOD_RES 52 52 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 159 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:Compara.
 GO:0000243; C:commitment complex; IEA:HAMAP.
 GO:0005685; C:U1 snRNP; IEA:HAMAP.
 GO:0071004; C:U2-type prespliceosome; IEA:HAMAP.
 GO:0003729; F:mRNA binding; IEA:HAMAP.
 GO:0003727; F:single-stranded RNA binding; IEA:Compara.
 GO:0030619; F:U1 snRNA binding; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0000395; P:mRNA 5'-splice site recognition; IEA:HAMAP.
 GO:0000387; P:spliceosomal snRNP assembly; IEA:HAMAP. 

Interpro

 IPR017340; U1_snRNP-C.
 IPR000690; Znf_C2H2_matrin.
 IPR003604; Znf_U1.
 IPR013085; Znf_U1-C. 

Pfam

 PF06220; zf-U1 

SMART

 SM00451; ZnF_U1 

PROSITE

 PS50171; ZF_MATRIN 

PRINTS