CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027306
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 
Protein Synonyms/Alias
  
Gene Name
 murF 
Gene Synonyms/Alias
 LA_1464 
Created Date
 July 27, 2013 
Organism
 Leptospira interrogans serogroup Icterohaemorrhagiae serovar La 
NCBI Taxa ID
 189518 
Lysine Modification
Position
Peptide
Type
References
124AVTGSSGKTTTKELLmethylation[1]
Reference
 [1] High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans.
 Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH, Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R.
 Cell Res. 2010 Feb;20(2):197-210. [PMID: 19918266] 
Functional Description
 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Ligase; Nucleotide-binding; Peptidoglycan synthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 466 AA 
Protein Sequence
MKSNFYYDPE TIRRVLGSTS ETWYHKEPLI TTITTSSTEA EENSLFVPLL GNRDGHEFIR 60
DAISKGATYF LVEENHPIYK NLNLEEKSKA IPVKNTLTAL GKLASFHRSR FDPIVIAVTG 120
SSGKTTTKEL LGNCLKNLEE SALVVTEKNY NNEIGLPFTL FKISDQTRVV VCELGMNHKG 180
EISRLSQIAK PDYAIITTIG TAHIEFLESQ KNIAKAKGEI VEGLKKGGKL FYPNTGEYSK 240
ILKNKTRKHG NKLVLTKSDK IFSILQKKSS GFLLEYKNKK IQWNLPGEKL LENLSVAITC 300
LEAIGTPQEW IQEGIHSFKS SNKRLDLQNG KYSVINDTYN ANYESMISSL EVADQLADGK 360
EFYAVLGDMK ELGEYSKEFH KKLGKKCSEF QNLKGLYTFG TDSFWIQEEF VKRTSSPRFS 420
EHFPGTQEGL SELIHKFLQT IPEGSIVLAK ASRGIQLERF VEALPV 466 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0047480; F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity; IEA:EC.
 GO:0008766; F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. 
Interpro
 IPR004101; Mur_ligase_C.
 IPR013221; Mur_ligase_cen.
 IPR000713; Mur_ligase_N.
 IPR005863; UDP-N-AcMur-pentapeptide_synth. 
Pfam
 PF01225; Mur_ligase
 PF02875; Mur_ligase_C
 PF08245; Mur_ligase_M 
SMART
  
PROSITE
  
PRINTS