| Tag | Content |
|---|
| CPLM ID | CPLM-018498 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sn1-specific diacylglycerol lipase beta |
Protein Synonyms/Alias | DGL-beta |
Gene Name | Daglb |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 477 | PPRGLLSKSLYEYSK | ubiquitination | [1] | | 585 | SPLDSPTKYPTLYPP | ubiquitination | [1] | | 627 | AHEAEFSKILIGPKM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). |
Sequence Annotation | ACT_SITE 443 443 Charge relay system (By similarity).
ACT_SITE 495 495 Charge relay system (By similarity).
MOD_RES 570 570 Phosphoserine (By similarity).
MOD_RES 578 578 Phosphoserine (By similarity). |
Keyword | Calcium; Cell membrane; Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 669 AA |
Protein Sequence | MPGMVLFGRR WSLASDDLVF PGSFELFLRV LWWIVSLTLY LTHRRRLDCP GGVLLSTYLI 60
VLLVLLAVII CTVLAIVCVS MRGTICNPGP RKSMSKLLYI RLALFLPEMV WASLGAAWVA 120
KGIQCDRTVV IGIIATVIVS WIVIAATMVT IIFVFDPLGG KMAPYPPCIP EHLDSNSSNR 180
LLTGLKTAAK SVWETRVQFC CCCVGQDDNT RVAFSSTADL FSTYFSDTDL VPSDIAAGFT 240
LLHQQQDNIS HSREPPEVVT HTPGQPQETE LDAEVENCHH YMPFAAAAYG WPLYIYRNPF 300
TGLCRIGGDC CRARDIEYDA VEGDQHNCHF ASILKTTGLQ YRDFIHISFH DKVYELPFIV 360
VLDHRKESVV VAVRGTMSLQ DVLTDLSAES ETLELGIELQ DCVAHKGIAQ AARYIHRRLV 420
NDGILSQAFS VAPEYQLVLV GHSLGAGAAA LLAIMLRGAY PQVRAYAFSP PRGLLSKSLY 480
EYSKDFVVSL ILGMDVIPRL SVTNMEDLKR RILRVIANCN KPKYKILLHG CWYGLFGGSP 540
DNFPTELDEG TQGALTQPLL GEQTLLTRYS PGYCSSDSPL DSPTKYPTLY PPGRIIHLEE 600
EGGSGRFGCC SAAQYRARWA HEAEFSKILI GPKMLIDHMP DVMIRALDRV LADRTACVSC 660
PGQGGSSVP 669 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004806; F:triglyceride lipase activity; IEA:InterPro. GO:0019369; P:arachidonic acid metabolic process; IMP:MGI. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0007405; P:neuroblast proliferation; IMP:MGI. GO:0042136; P:neurotransmitter biosynthetic process; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |