UniProt Accession

 CDD_MOUSE; P56389; Q9D7V3 

Genbank Protein ID

 AK008793; BC050114 

Genbank Nucleotide ID

 BAB25898.1; AAH50114.1 

Protein Name

 Cytidine deaminase 

Protein Synonyms/Alias

 Cytidine aminohydrolase 

Gene Name

 Cda 

Gene Synonyms/Alias

 Cdd 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
73	AERTAIQKAISEGYK	ubiquitination	[1]
80	KAISEGYKDFRAIAI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity). 

Sequence Annotation

 DOMAIN 16 117 CMP/dCMP deaminase zinc-binding.
 REGION 54 56 Substrate binding.
 ACT_SITE 67 67 Proton donor.
 METAL 65 65 Zinc; catalytic.
 METAL 99 99 Zinc; catalytic.
 METAL 102 102 Zinc; catalytic.  

Keyword

 3D-structure; Complete proteome; Hydrolase; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0004126; F:cytidine deaminase activity; ISS:UniProtKB.
 GO:0001882; F:nucleoside binding; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
 GO:0045980; P:negative regulation of nucleotide metabolic process; ISS:UniProtKB.
 GO:0051289; P:protein homotetramerization; ISS:UniProtKB. 

Interpro

 IPR016192; APOBEC/CMP_deaminase_Zn-bd.
 IPR002125; CMP_dCMP_Zn-bd.
 IPR006262; Cyt_deam_tetra.
 IPR016193; Cytidine_deaminase-like. 

Pfam

 PF00383; dCMP_cyt_deam_1 

SMART

  

PROSITE

 PS00903; CYT_DCMP_DEAMINASES 

PRINTS