UniProt Accession

 RAB23_MOUSE; P35288 

Genbank Protein ID

 Z22821; BC025578; M79305 

Genbank Nucleotide ID

 CAA80474.1; AAH25578.1; AAK14829.1 

Protein Name

 Ras-related protein Rab-23 

Protein Synonyms/Alias

 Protein open brain; Rab-15 

Gene Name

 Rab23 

Gene Synonyms/Alias

 Opb 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
132	LLDDSCIKNEEAEGL	acetylation	[1]
132	LLDDSCIKNEEAEGL	ubiquitination	[2]
163	LNVSEVFKYLAEKHL	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes (By similarity). Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. 

Sequence Annotation

 NP_BIND 16 23 GTP (By similarity).
 NP_BIND 64 68 GTP (By similarity).
 NP_BIND 121 124 GTP (By similarity).
 MOTIF 38 46 Effector region (By similarity).
 MOD_RES 234 234 Cysteine methyl ester (Potential).
 LIPID 234 234 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Developmental protein; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005776; C:autophagic vacuole; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; IDA:UniProtKB.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0000045; P:autophagic vacuole assembly; ISS:UniProtKB.
 GO:0006968; P:cellular defense response; ISS:UniProtKB.
 GO:0097094; P:craniofacial suture morphogenesis; ISS:UniProtKB.
 GO:0021904; P:dorsal/ventral neural tube patterning; IMP:UniProtKB.
 GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
 GO:0045861; P:negative regulation of proteolysis; IMP:MGI.
 GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:UniProtKB.
 GO:0001843; P:neural tube closure; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0008589; P:regulation of smoothened signaling pathway; IGI:MGI.
 GO:0007165; P:signal transduction; IMP:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0021513; P:spinal cord dorsal/ventral patterning; IMP:MGI. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.