UniProt Accession

 H3BPS5_HUMAN; H3BPS5 

Genbank Protein ID

 AC092723 

Genbank Nucleotide ID

  

Protein Name

 Interferon regulatory factor 8 

Protein Synonyms/Alias

  

Gene Name

 IRF8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	QPGLPGTKLYGPEGL	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0042742; P:defense response to bacterium; IEA:Compara.
 GO:0042832; P:defense response to protozoan; IEA:Compara.
 GO:0006955; P:immune response; IEA:Compara.
 GO:0030099; P:myeloid cell differentiation; IEA:Compara.
 GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Compara.
 GO:0006909; P:phagocytosis; IEA:Compara.
 GO:0032729; P:positive regulation of interferon-gamma production; IEA:Compara.
 GO:0032735; P:positive regulation of interleukin-12 production; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara. 

Interpro

 IPR019471; Interferon_reg_factor-3.
 IPR017855; SMAD_dom-like.
 IPR008984; SMAD_FHA_domain. 

Pfam

 PF10401; IRF-3 

SMART

  

PROSITE

  

PRINTS