UniProt Accession

 EHD2_HUMAN; Q9NZN4; B2RDH9; Q96CB6 

Genbank Protein ID

 AF181263; AF454952; AK315548; CH471126; BC014445 

Genbank Nucleotide ID

 AAF40470.1; AAL51078.1; BAG37926.1; EAW57505.1; AAH14445.1 

Protein Name

 EH domain-containing protein 2 

Protein Synonyms/Alias

 PAST homolog 2 

Gene Name

 EHD2 

Gene Synonyms/Alias

 PAST2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	RTVTSALKELYRTKL	ubiquitination	[1]
124	DPDKPFRKLNPFGNT	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Required for translocation of FER1L5 to the plasma membrane. Binds ATP; does not bind GTP (By similarity). 

Sequence Annotation

 DOMAIN 449 537 EH.
 DOMAIN 481 516 EF-hand.
 NP_BIND 65 72 ATP (By similarity).
 BINDING 220 220 ATP (By similarity).
 BINDING 258 258 ATP (By similarity).
 MOD_RES 438 438 Phosphoserine.
 MOD_RES 468 468 Phosphoserine.  

Keyword

 ATP-binding; Calcium; Cell membrane; Complete proteome; Direct protein sequencing; Endosome; Hydrolase; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 543 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0030866; P:cortical actin cytoskeleton organization; IEA:Compara.
 GO:0032456; P:endocytic recycling; IGI:UniProtKB.
 GO:0006897; P:endocytosis; IEA:Compara.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:2001137; P:positive regulation of endocytic recycling; ISS:UniProtKB.
 GO:1901741; P:positive regulation of myoblast fusion; ISS:UniProtKB.
 GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB. 

Interpro

 IPR001401; Dynamin_GTPase.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000261; EPS15_homology.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00350; Dynamin_N 

SMART

 SM00027; EH 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50031; EH 

PRINTS