| Tag | Content |
|---|
| CPLM ID | CPLM-017145 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proline-, glutamic acid- and leucine-rich protein 1 |
Protein Synonyms/Alias | Modulator of non-genomic activity of estrogen receptor; Transcription factor HMX3 |
Gene Name | PELP1 |
Gene Synonyms/Alias | HMX3; MNAR |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 216 | ACGSLKGKLASFFLS | ubiquitination | [1] | | 641 | GKPSAPKKLKLDVGE | ubiquitination | [1] | | 657 | MAPPSHRKGDSNANS | ubiquitination | [1] | | 686 | LMCGPLIKEETHRRL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. |
Sequence Annotation | MOTIF 33 37 LXXLL motif 1.
MOTIF 69 73 LXXLL motif 2.
MOTIF 111 115 LXXLL motif 3.
MOTIF 155 159 LXXLL motif 4.
MOTIF 177 181 LXXLL motif 5.
MOTIF 264 268 LXXLL motif 6.
MOTIF 271 275 LXXLL motif 7.
MOTIF 364 368 LXXLL motif 8.
MOTIF 459 463 LXXLL motif 9.
MOTIF 579 583 LXXLL motif 10.
MOTIF 584 588 LXXLL motif 11.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 13 13 Phosphoserine (By similarity).
MOD_RES 477 477 Phosphoserine.
MOD_RES 481 481 Phosphoserine.
MOD_RES 488 488 Phosphothreonine.
MOD_RES 745 745 Phosphothreonine.
MOD_RES 1033 1033 Phosphoserine.
MOD_RES 1043 1043 Phosphoserine. |
Keyword | Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1130 AA |
Protein Sequence | MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN 60
RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP 120
TELFQQHCVS WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL 180
LTSLLGLRPE CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY 240
SRLPSLGAGF SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS 300
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNIVSGI 360
CHLFRALAQD TRQPGKYWGP ESPQTVSSWS PSQRASTFVQ ITSLPMCRDT GAQCQSVANA 420
SLGEGEFGDS AESLLRGPAI LLTFHPGSIL EDRGLILLGE MRSGVGFLTY VYICKWSFPV 480
SVSLWLSLSS STLYLCPFFL QSLHGDGPLR LLLLPSIHLE ALDLLSALIL ACGSRLLRFG 540
ILIGRLLPQV LNSWSIGRDS LSPGQERPYS TVRTKVYAIL ELWVQVCGAS AGMLQGGASG 600
EALLTHLLSD ISPPADALKL RSPRGSPDGS LQTGKPSAPK KLKLDVGEAM APPSHRKGDS 660
NANSDVCAAA LRGLSRTILM CGPLIKEETH RRLHDLVLPL VMGVQQGEVL GSSPYTSSRC 720
RRELYCLLLA LLLAPSPRCP PPLACALQAF SLGQREDSLE VSSFCSEALV TCAALTHPRV 780
PPLQPMGPTC PTPAPVPPPE APSPFRAPPF HPPGPMPSVG SMPSAGPMPS AGPMPSAGPV 840
PSARPGPPTT ANHLGLSVPG LVSVPPRLLP GPENHRAGSN EDPILAPSGT PPPTIPPDET 900
FGGRVPRPAF VHYDKEEASD VEISLESDSD DSVVIVPEGL PPLPPPPPSG ATPPPIAPTG 960
PPTASPPVPA KEEPEELPAA PGPLPPPPPP PPPVPGPVTL PPPQLVPEGT PGGGGPPALE 1020
EDLTVININS SDEEEEEEEE EEEEEEEEEE EEEDFEEEEE DEEEYFEEEE EEEEEFEEEF 1080
EEEEGELEEE EEEEDEEEEE ELEEVEDLEF GTAGGEVEEG APPPPTLPPA LPPPESPPKV 1140
QPEPEPEPGL LLEVEEPGTE EERGADTAPT LAPEALPSQG EVEREGESPA AGPPPQELVE 1200
EEPSAPPTLL EEETEDGSDK VQPPPETPAE EEMETETEAE ALQEKEQDDT AAMLADFIDC 1260
PPDDEKPPPP TEPDS 1275 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0071339; C:MLL1 complex; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |