CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017317
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Spindle and centriole-associated protein 1 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 52; Spindle and centriole-associated protein 
Gene Name
 SPICE1 
Gene Synonyms/Alias
 CCDC52; SPICE 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
79ALKRKWRKQKPETLNubiquitination[1]
260LNATNAVKRLQTRLQubiquitination[1]
311HALSKPKKNISSGSTubiquitination[1]
451ISLTHAIKNCPVINNubiquitination[1]
508PQEELPVKLSQVPDPubiquitination[1]
575PTVEIIEKEQNWEEKubiquitination[1]
582KEQNWEEKTLPIDTDubiquitination[1]
683TLQNSAIKAHMNNIIubiquitination[1]
744QSMEARGKLLQLIEQubiquitination[1, 2]
795AEAPESSKCSTVSPVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. 
Sequence Annotation
 MOD_RES 644 644 Phosphoserine.
 MOD_RES 760 760 Phosphoserine.
 MOD_RES 764 764 Phosphoserine.  
Keyword
 Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 855 AA 
Protein Sequence
MSFVRVNRCG PRVGVRKTPK VKKKKTSVKQ EWDNTVTDLT VHRATPEDLV RRHEIHKSKN 60
RALVHWELQE KALKRKWRKQ KPETLNLEKR RLSIMKEILS DQYQMQDVLE KSDHLIAAAK 120
ELFPRRRTGF PNVTVAPDSS QGPIVVNQDP ITQSIFNESV IEPQALNDVD GEEEGTVNSQ 180
SGESENENEL DNSLNSQSNT NTDRFLQQLT EENFELISKL WTDIQQKIAT QSQITPPGTP 240
SSALSSGEQR AALNATNAVK RLQTRLQPEE STETLDSSYV VGHVLNSRKQ KQLLNKVKRK 300
PNLHALSKPK KNISSGSTTS ADLPNRTNSN LDVLKHMIHE VEHEMEEYER WTGREVKGLQ 360
SSQGLTGFTL SLVSSLCRLV RYLKESEIQL RKEVETRQQL EQVLGDHREL IDALTAEILR 420
LREENAATQA RLQQYMVTTD EQLISLTHAI KNCPVINNRQ EIQASESGAT GRRVMDSPER 480
PVVNANVSVP LMFREEVAEF PQEELPVKLS QVPDPPDNMN LAKNFPAHIF EPAVLLTPPR 540
QKSNLKFSPL QDVLRRTVQT RPAPRLPPTV EIIEKEQNWE EKTLPIDTDI QNSSEENRLF 600
TQRWRVSHMG EDLENKTQAP FVNLSQPLCN SHSNTQQSRS PTFSEELPVL GDGQQLRTNE 660
SLIQRKDIMT RIADLTLQNS AIKAHMNNII EPRGEQGDGL RELNKQESAS DMTSTFPVAQ 720
SLTPGSMEER IAELNRQSME ARGKLLQLIE QQKLVGLNLS PPMSPVQLPL RAWTEGAKRT 780
IEVSIPGAEA PESSKCSTVS PVSGINTRRS SGATGNSCSP LNATSGSGRF TPLNPRAKIE 840
KQNEEGWFAL STHVS 855 
Gene Ontology
 GO:0005814; C:centriole; IDA:UniProtKB.
 GO:0005819; C:spindle; IDA:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051310; P:metaphase plate congression; IMP:UniProtKB.
 GO:0046599; P:regulation of centriole replication; IMP:UniProtKB.
 GO:0090307; P:spindle assembly involved in mitosis; IMP:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS