| Tag | Content |
|---|
| CPLM ID | CPLM-024617 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glutamate receptor ionotropic, kainate 3 |
Protein Synonyms/Alias | GluK3; Glutamate receptor 7; GluR-7; GluR7 |
Gene Name | Grik3 |
Gene Synonyms/Alias | Glur7 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 367 | GRFMNFIKEAQWEGL | phosphoglycerylation | [1] |
|
Reference | [1] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Moellering RE, Cravatt BF. Science. 2013 Aug 2;341(6145):549-53. [ PMID: 23908237] |
Functional Description | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). |
Sequence Annotation | REGION 690 692 Glutamate binding (By similarity).
BINDING 520 520 Glutamate (By similarity).
BINDING 525 525 Glutamate (By similarity).
BINDING 739 739 Glutamate (By similarity).
CARBOHYD 76 76 N-linked (GlcNAc...) (Potential).
CARBOHYD 278 278 N-linked (GlcNAc...) (Potential).
CARBOHYD 381 381 N-linked (GlcNAc...) (Potential).
CARBOHYD 415 415 N-linked (GlcNAc...) (Potential).
CARBOHYD 426 426 N-linked (GlcNAc...) (Potential).
CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
DISULFID 99 350 By similarity. |
Keyword | Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 919 AA |
Protein Sequence | MTAPWRRLRS LVWEYWAGFL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA QVMNAEEHAF 60
RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD QLALGVVAIF GPSQGSCTNA 120
VQSICNALEV PHIQLRWKHH PLDNKDTFYV NLYPDYASLS HAILDLVQSL KWRSATVVYD 180
DSTGLIRLQE LIMAPSRYNI RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ 240
ILKQAMAMGM MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWA 300
MERLQAAPRA ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC HRHKAWRFGG 360
RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED GLEKVGVWSP ADGLNITEVA 420
KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR KSDRTLYGND RFEGYCIDLL KELAHILGFS 480
YEIRLVEDGK YGAQDDKGQW NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV 540
SILYRKPNGT NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG 600
SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII SSYTANLAAF 660
LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK ISTFEKMWAF MSSKPSALVK 720
NNEEGIQRTL TADYALLMES TTIEYITQRN CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT 780
IAILQLQEED KLHIMKEKWW RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV 840
GEFIYKLRKT AEREQRSFCS TVADEIRFSL TCQRRLKHKP QPPMMVKTDA VINMHTFNDR 900
RLPGKDSMSC STSLAPVFP 919 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005887; C:integral to plasma membrane; IEA:Compara. GO:0005886; C:plasma membrane; IDA:MGI. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0001640; F:adenylate cyclase inhibiting G-protein coupled glutamate receptor activity; IEA:Compara. GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro. GO:0004970; F:ionotropic glutamate receptor activity; ISS:UniProtKB. GO:0015277; F:kainate selective glutamate receptor activity; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |